SIMULTANEOUS DETERMINATION OF MICELLAR DISSOCIATION CONCENTRATION AND CRITICAL MICELLAR CONCENTRATION OF BILE SALTS BY pH MEASUREMENTS
SIMULTANEOUS DETERMINATION OF MICELLAR DISSOCIATION CONCENTRATION AND CRITICAL MICELLAR CONCENTRATION OF BILE SALTS BY pH MEASUREMENTS
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通过 pH 测量同时测定胆汁盐的胶束解离浓度和临界胶束浓度
DOI：
10.1080/01932699208943341
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发表时间：
1992
影响因子：
2.2
通讯作者：
Kun
中科院分区：
文献类型：
--
作者：
Y. Chiu;Kun
本文介绍了一种用pH计测定胶束解离浓度(MDC)的方法。8种胆盐样品的临界胶束浓度(CMC)：胆酸钠(NAC)、脱氧胆酸钠(NADC)、甘胆酸钠(NAGC)、甘氨酸脱氧胆酸钠(NaGDC)、甘氨酸鹅脱氧胆酸钠(NaGCDC)、牛磺胆酸钠(NATC)、牛磺酸脱氧胆酸钠(NaTDC)和牛磺酸鹅脱氧胆酸钠(NaTCDC)。实验通过用新鲜蒸馏水稀释胆盐溶液，并在25℃下用氢离子电极跟踪pH变化来进行，大多数胆盐溶液的pH-浓度图都出现一个断裂，表明MDC。然而，NAC和NADC样品出现了两个中断，意味着MDC和CMC。MDC和CMC值与表面张力法和浊度法测定的值以及文献报道的数据符合得很好。该方法具有快速、简便、不需取样等优点。
ABSTRACT This paper demonstrates a method of using a pH meter to determine the micellar dissociation concentration (mdc) and the. critical micellar concentration (cmc) of eight bile salt samples: sodium cholate (NaC), sodium deoxycholate (NaDC), sodium glycocholate (NaGC), sodium glycodeoxycholate (NaGDC), sodium glyco-chenodeoxycholate (NaGCDC), sodium taurocholate (NaTC), sodium taurodeoxycholate (NaTDC) and sodium taurochenodeoxycholate (NaTCDC). The experiments were performed by diluting the bile salt solutions with freshly distilled water and following the pH changes with a hydrogen ion electrode at 25°C. One break appears in most of the pH-concentration plots of the bile salt solutions, signifying mdc. However, two breaks appear for NaC and NaDC samples, signifying mdc and cmc. The mdc and cmc values are in good agreement with values determined by surface tension and turbidity methods and with data reported in the literature. The method described in this paper is quick, simple and requiring no sampl...