N-Heterocyclic Carbene (NHC)-Catalyzed Intermolecular Hydroacylation of Cyclopropenes
N-Heterocyclic Carbene (NHC)-Catalyzed Intermolecular Hydroacylation of Cyclopropenes
复制标题
DOI：
10.1021/ja202594g
复制
发表时间：
2011-06-01
影响因子：
15
通讯作者：
Glorius, Frank
中科院分区：
文献类型：
--
作者：
Bugaut, Xavier;Liu, Fan;Glorius, Frank
我们报告了第一个分子间 NHC 催化的电子中性烯烃的加氢酰化反应。在温和条件下用环丙烯处理芳香醛，可以得到有价值的酰基环丙烷，产率中等至高，并且具有优异的非对映控制水平。初步机制研究表明产物形成是通过协调一致的顺式氢酰化途径发生的。
We report the first intermolecular NHC-catalyzed hydroacylation of electron-neutral olefins. Treatment of aromatic aldehydes with cyclopropenes under mild conditions affords valuable acylcyclopropanes in moderate to high yields with an excellent level of diastereocontrol. Preliminary mechanistic studies suggest that product formation occurs via a concerted syn hydroacylation pathway.