Fibronectin matrix deposition and cell contractility - Implications for airway remodeling in asthma
Fibronectin matrix deposition and cell contractility - Implications for airway remodeling in asthma
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DOI：
10.1378/chest.122.6_suppl.275s
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发表时间：
2002-12-01
期刊：
影响因子：
9.6
通讯作者：
Hocking, DC
中科院分区：
文献类型：
--
作者：
Hocking, DC
细胞与细胞外基质（ECM）蛋白（纤维连接蛋白）的粘附在细胞生长、迁移、分化和ECM组织等复杂过程的调节和协调中起着重要作用。纤维连接蛋白在ECM中的沉积是一个细胞依赖性的过程，通常受到严格调节以确保受控的基质沉积。纤维连接蛋白和胶原蛋白在气道上皮下间隙的沉积增加。所有形式的哮喘都发生在疾病进展的早期。实验证据表明，纤维连接蛋白基质的积累通过改变气道的结构特性和气道壁细胞的功能特性来促进哮喘的进展。
The adhesion of cells to the extracellular matrix (ECM) protein, fibronectin, is important in the regulation and coordination of such complex processes as cell growth, migration, differentiation, and ECM organization. The deposition of fibronectin into the ECM is a cell-dependent process that is normally tightly regulated to ensure controlled matrix deposition. Increased deposition of fibronectin and collagen into the subepithelial space of the airways is observed in. all forms of asthma and occurs early in the progression of the disease. Experimental evidence suggests a model in which fibronectin matrix accumulation contributes to the progression of asthma by altering both the structural properties of the airways and the functional properties of cells of the airway wall.