Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract
Population based cohort study of the association between alcohol intake and cancer of the upper digestive tract
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DOI：
10.1136/bmj.317.7162.844
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发表时间：
1998-09-26
影响因子：
--
通讯作者：
Sorensen, TIA
中科院分区：
文献类型：
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作者：
Gronbæk, M;Becker, U;Sorensen, TIA
目的：探讨不同类型的酒精饮料与上消化道癌的关系设计：以人群为基础的研究，对啤酒、葡萄酒和烈酒的摄入量、吸烟习惯、教育水平和2-19年的随访进行基线评估，研究地点：丹麦。受试者：结果：在平均13.5年的随访中，156例受试者发生上消化道癌，其中男性117例，女性13063例，年龄20 ~ 98岁。与不饮酒者相比（饮用21种啤酒和烈酒但不喝葡萄酒的人与不喝酒的人相比，相对风险为5.2（2.7至10.2），而那些饮用相同数量但饮酒量中包括葡萄酒的人，相对风险为1.7（0.6 ~ 4.4）。结论：适量摄入葡萄酒可能不会增加患上消化道癌的风险，而适量摄入啤酒或烈酒则会显著增加患上消化道癌的风险。
Objective: To examine the relation between different types of alcoholic drinks and upper digestive tract cancers (oropharyngeal and oesophageal).Design: Population based study with baseline assessment or intake or beer, wine, and spirits, smoking habits, educational level, and 2-19 years' follow up on risk of upper digestive tract cancer.Setting: Denmark.Subjects: 15 117 men and 13 063 women aged 20 to 98 years.Main outcome measure: Number and time of identification of incident upper digestibe tract cancer during follow up.Results: During a mean follow up of 13.5 years, 156 subjects developed upper digestive tract cancer. Compared with non-drinkers (drinkers of 21 beers and spirits but no wine had a relative risk of 5.2 (2.7 to 10.2) compared with non-drinkers, whereas those who drank the same amount, but included wine in their alcohol intake, had a relative risk of 1.7 (0.6 to 4.4).Conclusion: A moderate intake of wine probably does not increase the risk of upper digestive tract cancer, whereas a moderate intake of beer or spirits increases the risk considerably.