A T2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach
A T2ex MRI Dy-based contrast agent for direct pH imaging using a ratiometric approach
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T-2ex MRI Dy 基造影剂，用于使用比例法直接 pH 成像
DOI：
10.1039/d0dt03734f
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发表时间：
2021-02-14
影响因子：
4
通讯作者：
Liu，Kai
中科院分区：
文献类型：
--
作者：
Zhang，Yi;Zhao，Kelu;Liu，Kai
PH值是在磁共振成像(MRI)绘制组织酸度图中发现独特应用的关键参数。这项研究报告了一系列基于Dy的MR探针，显示了创新的T2ex特征，受质子催化事件的支配。当pH从5.5增加到8.0时，r2ex的松弛系数急剧增加，而r1的松弛系数保持不变。由此得到的r2ex/r1允许不依赖于浓度并直接定位生理上相关的pH范围。
pH is a critical parameter that has found unique application in magnetic resonance imaging (MRI) mapping acidity in tissues. This study reports a series of Dy-based MR probes that show innovative T2ex features, governed by proton catalyzed events. With an increase of pH from 5.5 to 8.0, the r2ex relaxivity increased dramatically, while the r1 relaxivity remained unchanged. The resulting r2ex/r1 allowed for concentration-independent and direct mapping of physiologically relevant pH ranges.