Regulation of renin release and renal hemodynamics during acute and chronic verapamil administration.
Regulation of renin release and renal hemodynamics during acute and chronic verapamil administration.
复制标题
急性和慢性维拉帕米给药期间肾素释放和肾血流动力学的调节。
DOI：
10.1152/ajprenal.1990.258.4.f1105
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
LeDuff,JK
中科院分区：
文献类型：
--
作者：
Young,DB;Lin,HB;LeDuff,JK
在110和60 mmHg之间的肾灌注压控制水平下，在麻醉犬中分析了钙离子进入阻滞剂维拉帕米短期和长期给药对肾脏血流动力学和肾素释放调节的影响。对以下三组犬进行了研究：对照组、急性给药维拉帕米组（初始剂量为150 μ g/kg，随后为4 μ g.kg-1. min-1）和慢性给药维拉帕米组（240 mg，口服，每日两次）。在110 mmHg下，急性和慢性治疗组的肾血流量（RBF）分别比对照组高53%（P <0.03）和79%（P <0.01）。急性和慢性治疗组的肾小球滤过率（GFR）分别为64%和92%，高于对照组（P均小于0.01）。在对照组中，RBF和GFR的自动调节非常有效，而维拉帕米的急性和长期治疗严重受损。对照组和急性治疗组在110 mmHg下的肾素释放相似，分别为3.36 +/- 0.96和4.46 +/- 0.64 U.min-1.g-1，而慢性治疗组的释放速率为8.89 +/- 2.60 U.min-1.g-1（P <0.03）。随着灌注压的降低，急性治疗组的释放率上升到高于对照组的水平;在70 mmHg时，急性治疗组的释放率比对照组高88%（P <0.01）。维拉帕米深刻地改变了肾脏血流动力学和肾素释放的调节，其作用在短期和长期给药期间都很突出。
The effects of short- and long-term administration of the calcium-entry blocker verapamil on regulation of renal hemodynamics and renin release were analyzed in anesthetized dogs at controlled levels of renal perfusion pressure between 110 and 60 mmHg. The following three groups of dogs were studied: a control group, an acutely treated verapamil group (initial dose of 150 micrograms/kg followed by 4 micrograms.kg-1.min-1), and a chronically treated verapamil group (240 mg per os twice each day). At 110 mmHg the renal blood flow (RBF) in the acutely and chronically treated groups was 53% greater than (P less than 0.03) and 79% greater than (P less than 0.01) that of the control group. Glomerular filtration rate (GFR) in the acutely and chronically treated groups was 64 and 92%, respectively, greater than (P less than 0.01 for both) that of the control group. Autoregulation of RBF and GFR was extremely effective in the control group, whereas it was severely impaired by acute and long-term treatment with verapamil. Renin release at 110 mmHg in the control and the acutely treated groups were similar, 3.36 +/- 0.96 and 4.46 +/- 0.64 U.min-1.g-1, respectively, although in the chronically treated group the rate of release was 8.89 +/- 2.60 U.min-1.g-1 (P less than 0.03). As perfusion pressure was reduced, the rate of release from the acutely treated group rose to higher levels than that of the control group; at 70 mmHg release from the acutely treated group was 88% greater than that of the control group (P less than 0.01). Verapamil profoundly alters regulation of renal hemodynamics and renin release and the effect is prominent during both short- and long-term administration.