Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis.
Inhibition of ornithine or arginine decarboxylase as an experimental approach to African or American trypanosomiasis.
复制标题
抑制鸟氨酸或精氨酸脱羧酶作为非洲或美洲锥虫病的实验方法。
DOI：
10.1007/978-1-4684-5637-0_64
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发表时间：
1988
影响因子：
--
通讯作者：
Sjoerdsma,A
中科院分区：
文献类型：
--
作者：
McCann,PP;Bacchi,CJ;Bitonti,AJ;Kierszenbaum,F;Sjoerdsma,A
最近多胺研究的一个更有价值的领域是阐明它们在原生动物生长中的作用（Pegg和McCann，1982; 1988）。Bacchi等人（1980）发现α-二氟甲基鸟氨酸（DFMO）（一种特异性的鸟氨酸脱羧酶催化抑制剂）可完全治愈非洲锥虫的急性感染，这是寄生原生动物对多胺领域影响的第一个迹象。B.小鼠布氏杆菌。这一戏剧性的发现导致DFMO在非洲的抗药性晚期人类昏睡病的致命病例中的显著快速使用（Schechter等人，1987年）。
One of the more rewarding areas of recent research in polyamines has been the elucidation of their role in protozoal growth (Pegg and McCann, 1982; 1988). The first indication of the impact that parasitic protozoa would have on the polyamine field was the discovery by Bacchi et al. (1980) that α-difluoromethylornithine (DFMO), a specific catalytic inhibitor of ornithine decarboxylase, would totally cure acute infections of the African trypanosomeT. b. bruceiin mice. This dramatic finding led to the remarkably swift use of DFMO in what would have been fatal cases of drug-resistant late-stage human sleeping sickness in Africa (Schechter et al., 1987).