CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
CSF biomarkers for Alzheimer disease correlate with cortical brain biopsy findings
复制标题
DOI：
10.1212/wnl.0b013e3182563bd0
复制
发表时间：
2012-05-01
期刊：
影响因子：
9.9
通讯作者：
Herukka, S. -K.
中科院分区：
文献类型：
--
作者：
Seppala, T. T.;Nerg, O.;Herukka, S. -K.
目的：评估额叶皮质脑活检中阿尔茨海默病（AD）相关病理变化与脑室与腰椎CSF中AD生物标志物之间的关系，并评估CSF和皮质活检中AD生物标志物与AD最终临床诊断的关系。182例正常压力脑积水患者（152例已知APOE携带者），皮质脑活检中的A β斑块和tau蛋白与脑室和腰椎CSF中的A β 42、总tau蛋白和p-tau蛋白水平相关（通过ELISA测定）。在平均随访2.0年，51例AD dementions.Results：A β 42斑块的皮质活检的患者有较低的（p = 0.009）CSF A β 42水平比那些没有A β斑块。与皮质活检中无tau的患者相比，皮质活检中有tau的患者CSF中A β 42较低（p = 0.014），但p-tau 181较高（p = 0.015）。具有淀粉样蛋白+ tau +活检的患者在CSF中具有最低的A β 42和最高的tau和p-tau 181水平。与相应的腰椎CSF样本相比，心室中的A β 42水平较低，tau和p-tau 181较高。在多变量分析中，皮质A β的存在是独立预测的载脂蛋白E β 4载体状态和年龄，但不是由CSF A β 42或tau levels.Conclusions：淀粉样斑块和过度磷酸化的tau在皮质脑活检反映低CSF A β 42和高CSF tau和p-tau水平，分别。神经病学（R）2012;78：1568-1575
Objective: To assess the relationship between Alzheimer disease (AD)-related pathologic changes in frontal cortical brain biopsy and AD biomarkers in ventricular vs lumbar CSF, and to evaluate the relationships of AD biomarkers in CSF and cortical biopsy with the final clinical diagnosis of AD.Methods: In 182 patients with presumed normal pressure hydrocephalus (152 with known APOE carrier status), A beta plaques and tau in the cortical brain biopsies were correlated with the ventricular and lumbar CSF A beta 42, total tau, and p-tau levels measured by ELISA. In a median follow-up of 2.0 years, 51 patients developed AD dementia.Results: The patients with A beta 42 plaques in the cortical biopsy had lower (p = 0.009) CSF A beta 42 levels than those with no A beta plaques. The patients with tau in the cortical biopsy had lower (p = 0.014) A beta 42 but higher (p = 0.015) p-tau 181 in CSF as compared to those with no tau in the cortical biopsy. The patients with amyloid + tau + biopsies had the lowest A beta 42 and highest tau and p-tau 181 levels in CSF. The A beta 42 levels were lower and the tau and p-tau 181 higher in the ventricular vs corresponding lumbar CSF samples. In multivariate analysis, the presence of cortical A beta was independently predicted by the APOE epsilon 4 carrier status and age but not by CSF A beta 42 or tau levels.Conclusions: Amyloid plaques and hyperphosphorylated tau in cortical brain biopsies are reflected by low CSF A beta 42 and high CSF tau and p-tau levels, respectively. Neurology (R) 2012;78:1568-1575