FEEDING-INDUCED INCREASE IN THE EXTRACELLULAR CONCENTRATION OF HISTAMINE IN RAT HYPOTHALAMUS AS MEASURED BY INVIVO MICRODIALYSIS
FEEDING-INDUCED INCREASE IN THE EXTRACELLULAR CONCENTRATION OF HISTAMINE IN RAT HYPOTHALAMUS AS MEASURED BY INVIVO MICRODIALYSIS
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DOI：
10.1016/0304-3940(91)90037-t
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发表时间：
1991-04-29
影响因子：
2.5
通讯作者：
SAEKI, K
中科院分区：
文献类型：
--
作者：
ITOH, Y;OISHI, R;SAEKI, K
用在体微透析法测定清醒和自由活动大鼠下丘脑细胞外组胺（HA）浓度，并观察禁食和进食对HA浓度的影响。在非禁食大鼠中，基础HA浓度几乎是恒定的，从11.00至17.00小时的透析探针植入后的第二天，平均值为11.1 pg/30 min。没有观察到显着变化的HA浓度在大鼠剥夺食物24小时。在24小时禁食大鼠，喂养15分钟产生了短暂的和显着的增加HA浓度。这些结果表明，大鼠下丘脑的组胺能活性增加，在喂养过程中。
The extracellular concentration of histamine (HA) in the hypothalamus of conscious and freely moving rats was measured by in vivo microdialysis and the effects of fasting and feeding on the HA concentration were examined. In non-fasted rats, the basal HA concentration was almost constant from 11.00 to 17.00 h on the day following implantation of the dialysis probe, the mean value being 11.1 pg/30 min. No significant change in the HA concentration was observed in rats deprived of food for 24 h. In 24-h fasted rats, feeding for 15 min produced a transient and significant increase in the HA concentration. These results suggest that histaminergic activity in the rat hypothalamus increases during feeding.