A PCL/cellulose coil-shaped scaffoldviaa modified electrohydrodynamic jetting process
A PCL/cellulose coil-shaped scaffoldviaa modified electrohydrodynamic jetting process
复制标题
改进电液动力喷射工艺制备PCL/纤维素卷状支架
DOI：
10.1080/17452759.2020.1808269
复制
发表时间：
2020-08-19
影响因子：
10.6
通讯作者：
Kim, Geun Hyung
中科院分区：
文献类型：
--
作者：
Choe, Young Eun;Kim, Geun Hyung
Scaffolds are regarded as a key factor for tissue engineering as they provide a three-dimensional structural frame for host cells to attach, proliferate, and differentiate. Recently, 3D bioprinting has enabled the quick and versatile fabrication of various architectures of micro/macroscale scaffolds, but there remain obstacles to successful tissue regeneration, such as large strut diameter and simple pore geometry and distribution. To overcome these deficiencies, we propose a new scaffold, which was fabricated using polycaprolactone (PCL)/cellulose and electrohydrodynamic jetting (EHDJ), composed of a spring-shaped strut and controllable macro/micropores. In this work, PCL provided reasonable mechanical strength and synergistic effects with cellulose, which homogeneously covered the PCL surface. Furthermore, the homogeneously distributed cellulose promoted meaningful cellular activities. By manipulating various processing parameters, we fabricated a stable coil-shaped scaffold and evaluated it for physical characteristics andin vitrocellular activities, including osteogenic activities, using MG63 cells. Consequently, the coil-shaped scaffold exhibited a significantly higher degree of cellular activity than the controls (PCL coil-shaped scaffold and PCL coil-shaped scaffold dipped in cellulose). Based on our results, the coil-shaped structure could represent a scaffold with high potential for use in hard tissue regeneration.
