Redox Imbalance in the Colonic Mucosa of Ulcerative Colitis
Redox Imbalance in the Colonic Mucosa of Ulcerative Colitis
复制标题
溃疡性结肠炎结肠粘膜氧化还原失衡
DOI：
10.1080/00365520310005055
复制
发表时间：
2003
影响因子：
1.9
通讯作者：
Fujimoto K.
中科院分区：
文献类型：
--
作者：
T. S.;Iwakiri R.;Ootani H.;Aw T. Y.;Fujimoto K.
溃疡性结肠炎（UC）是一种病因不明的炎症性肠病，其特征是结肠粘膜急性炎症、溃疡和出血的周期性变化。氧化应激被认为是UC粘膜损伤发病机制和持续存在的关键因素（1）。谷胱甘肽（GSH）是一种普遍存在于哺乳动物细胞中的高浓度三肽硫醇，是大多数组织抗氧化防御的重要组成部分。GSH以还原型谷胱甘肽或氧化型谷胱甘肽（GSSG）形式存在，细胞的氧化还原状态由主要以GSH形式分布的GSH和GSSG维持。这种氧化还原平衡是通过氧化还原循环酶的功能实现的。细胞暴露于氧化应激导致GSH/GSSG失衡和GSSG积累。这项研究是：1）研究活动性和非活动性UC状态下结肠粘膜氧化还原含量和GSH氧化态，2）检查该患者人群中GSH状态与治疗疗效之间的关系。
Ulcerative colitis (UC) is an inflammatory bowel disease of unknown cause and is characterized by cycles of acute inflammation, ulceration and bleeding of the colonic mucosa. Oxidative stress has been implicated to be a key factor in the pathogenesis and perpetuation of mucosal damage in UC (1). Glutathione (GSH) is a ubiquitous tripeptide-thiol present in high concentrations in mammalian cells, and is a significant component of the antioxidant defenses of most tissues. GSH exists either as reduced glutathione or oxidized glutathione (GSSG), and the cellular redox status is maintained by the distribution of GSH and GSSG predominantly as GSH. This redox balance is achieved by the function of the redox cycle enzymes. Exposure of cells to oxidant stress results in GSH/GSSG imbalance and the accumulation of GSSG. This study was undertaken: 1) to investigate the colon mucosal redox content and oxidation state of GSH in active and inactive UC states and 2) to examine the relationship between GSH status and efficacy of therapy in this patient population.
影响因子：
7.4
作者：
BABBS, CF
通讯作者：
BABBS, CF