The involvement of glia in long-term plasticity in the spinal dorsal horn of the rat
The involvement of glia in long-term plasticity in the spinal dorsal horn of the rat
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DOI：
10.1097/00001756-200210070-00017
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发表时间：
2002-10-07
期刊：
影响因子：
1.7
通讯作者：
Zhao, ZQ
中科院分区：
文献类型：
--
作者：
Ma, JY;Zhao, ZQ
我们研究了脊髓胶质细胞在诱导C纤维诱发的脊髓长期增强（LTP）中的潜在作用。坐骨神经强电刺激可引起脊髓背角c纤维诱发场电位的长期增强。鞘内注射氟柠檬酸盐（1 nmol）（一种胶质代谢抑制剂）后，破伤风刺激引起长期抑郁（LTD），但不引起LTP。犬尿酸或2-氨基-5-膦戊酸（AP-5）可消除氟柠檬酸的作用，但6,7-二硝基喹啉-2,3-二酮（DNQX）、微毒素或士的宁不能消除氟柠檬酸的作用。这些数据表明，脊髓胶质细胞可能通过NMDA受体调节伤害性神经元的中枢敏化。
We have examined the potential role of spinal glial cells in the induction of C fiber-evoked long-term potentiation (LTP) in the spinal cord. Tetanic stimulation of the sciatic nerve induced long-term potentiation of C-fiber-evoked field potentials in the spinal dorsal horn in all rats. Following intrathecal fluorocitrate (1 nmol), a glial metabolic inhibitor, tetanic stimulation induced long-term depression (LTD) but not LTP. The effects of fluorocitrate were abolished by kynurenic acid or 2-amino-5-phosphonovaleric acid (AP-5), but not by 6,7-dinitroquinoxaline-2,3-dione (DNQX), picrotoxin or strychnine. These data suggest that spinal glial cells may modulate the central sensitization of nociceptive neurons via NMDA receptors.