Roles for the type III TGF-beta receptor in human cancer.
Roles for the type III TGF-beta receptor in human cancer.
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DOI：
10.1016/j.cellsig.2010.01.016
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发表时间：
2010-08
影响因子：
4.8
通讯作者：
Blobe GC
中科院分区：
文献类型：
--
作者：
Gatza CE;Oh SY;Blobe GC
转化生长因子β（TGF-β）超家族配体以细胞类型和环境特异性方式在调节细胞稳态、胚胎发育、分化、增殖、免疫监视、血管生成、运动和凋亡中具有重要作用。TGF-β超家族信号通路在人类癌症中也具有不同的作用，其功能是抑制或促进癌症进展。TGF-β超家族共受体，III型TGF-β受体（TβRIII，也称为β聚糖）介导TGF-β超家族配体依赖性以及配体非依赖性信号传导至Smad和非Smad信号传导途径。TβRIII在癌症进展过程中表达的缺失以及TβRIII对调节细胞迁移、侵袭、增殖和血管生成的直接作用支持TβRIII作为癌症进展抑制剂和/或作为转移抑制剂的作用。明确TβRIII作用的生理功能和机制以及TβRIII功能在癌症进展过程中的改变，将使TβRIII和TβRIII介导的功能更有效地靶向用于人类癌症的诊断和治疗。
Transforming growth factor β (TGF-β) superfamily ligands have important roles in regulating cellular homeostasis, embryonic development, differentiation, proliferation, immune surveillance, angiogenesis, motility, and apoptosis in a cell type and context specific manner. TGF-β superfamily signaling pathways also have diverse roles in human cancer, functioning to either suppress or promote cancer progression. The TGF-β superfamily co-receptor, the type III TGF-β receptor (TβRIII, also known as betaglycan) mediates TGF-β superfamily ligand dependent as well as ligand independent signaling to both Smad and non-Smad signaling pathways. Loss of TβRIII expression during cancer progression and direct effects of TβRIII on regulating cell migration, invasion, proliferation, and angiogenesis support a role for TβRIII as a suppressor of cancer progression and/or as a metastasis suppressor. Defining the physiological function and mechanism of TβRIII action and alterations in TβRIII function during cancer progression should enable more effective targeting of TβRIII and TβRIII mediated functions for the diagnosis and treatment of human cancer.
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