Follow-up of breast lesions diagnosed as benign with stereotactic core-needle biopsy: Frequency of mammographic change and false-negative rate
Follow-up of breast lesions diagnosed as benign with stereotactic core-needle biopsy: Frequency of mammographic change and false-negative rate
复制标题
DOI：
10.1148/radiology.212.1.r99jl42189
复制
发表时间：
1999-07-01
期刊：
影响因子：
19.7
通讯作者：
Tocino, I
中科院分区：
文献类型：
--
作者：
Lee, CH;Philpotts, LE;Tocino, I
目的：确定在后续乳房 X 光检查中立体定向空芯针活检 (SCNB) 诊断为良性病变的频率，并确定最佳随访策略和延迟假阴性率。 材料和方法：从 1992 年 7 月到 1995 年 12 月，540 例 SCNB 产生良性结果的病例中，有 355 例 (66%) 采用后续乳房 X 光检查进行管理。其中 298 例 (84%) 接受了乳房 X 光检查随访。审查了后续乳房X光检查报告。当报告变化时，会审查活检前和活检后的乳房 X 光检查、病理报告以及随后的乳房 X 光检查随访结果。 结果：298 例中有 21 例 (7%) 发生乳房 X 光检查改变，间隔时间为 6-55 个月（平均 20 个月）。 21 例中有 10 例在初始乳腺 X 光检查稳定后发生变化。 21 例中的 18 例进行了重复活检。两例被诊断为恶性肿瘤； 1 例肿块在 6 个月时发生变化，1 例微钙化在 24 个月时发生变化。这代表了 2% 的延迟假阴性率（540 例活检中的 105 例恶性肿瘤中的 2 例）。结论：SCNB 诊断为良性的病例中，一小部分会在后续乳房 X 光检查中发生变化，这可能需要重复活检。这些结果表明，对 SCNB 产生非特异性良性结果的病例进行 6 个月随访，并对具有特定良性结果的病例每年进行乳房 X 光检查是一种合理的管理策略。
PURPOSE: To determine how often lesions diagnosed as benign with stereotactic core-needle biopsy (SCNB) change at follow-up mammography and to determine the optimal follow-up strategy and the delayed false-negative rate.MATERIALS AND METHODS: From July 1992 through December 1995, 355 of 540 cases (66%) in which SCNB yielded benign results were managed with follow-up mammography. Mammographic follow-up was available for 298 of these cases (84%). Follow-up mammography reports were reviewed. When a change was reported, pre- and postbiopsy mammograms, pathology reports, and results of subsequent mammographic follow-up were reviewed.RESULTS: Mammographic change occurred in 21 of 298 cases (7%) at intervals of 6-55 months (mean, 20 months). Change occurred after initial mammographic stability in 10 of 21 cases. Repeat biopsy was performed in 18 of 21 cases. Malignancy was diagnosed in two cases; one mass that changed at 6 months and one case of microcalcifications that changed at 24 months. This represented a delayed false-negative rate of 2% (two of 105 malignancies among 540 biopsies).CONCLUSION: A small percentage of cases diagnosed as benign with SCNB will change on follow-up mammograms, which may necessitate repeat biopsy. These results suggest that 6-month follow-up for cases that yield nonspecific benign results at SCNB and yearly screening mammography for cases with specific benign results is a reasonable management strategy.