Vascular physiology and long-term healing of partial ligament tears
Vascular physiology and long-term healing of partial ligament tears
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DOI：
10.1016/s0736-0266(02)00012-8
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发表时间：
2002-09-01
影响因子：
2.8
通讯作者：
Salo, PT
中科院分区：
文献类型：
--
作者：
Bray, RC;Leonard, CA;Salo, PT
前交叉韧带（ACL）损伤的功能结局通常比内侧副韧带（MCL）撕裂差。韧带损伤后，韧带愈合的所有阶段都需要充足的血液供应。我们假设ACL和MCL愈合特性的差异反映了它们对关节损伤的血管反应。本文研究了兔膝关节韧带直接损伤后以及后交叉韧带（PCL）切断引起慢性关节不稳定条件下的长期血流量和血管体积变化。16周后测量ACL和MCL的血流量和血管体积，并与对照组和假手术组动物进行比较，16周后，直接韧带损伤诱导ACL和MCL的标准化血流量和血管体积显著增加;然而，ACL的血管体积并不高于MCL的对照水平。我们的结论是，前交叉韧带和内侧副韧带的直接损伤会引起长期的生理反应，关节松弛是后交叉韧带损伤的常见后遗症。慢性关节松弛未能诱导ACL的适应性血管反应，而MCL显示出显著的血液供应放大。尽管MCL和ACL在PCL横断后均显示重量增加，但ACL中缺乏长期血管反应可能是其愈合潜力降低的主要因素。(C)2002骨科研究学会。由爱思唯尔科技有限公司出版。保留所有权利。
Functional outcomes of anterior cruciate ligament (ACL) injury are generally poorer than those of medial collateral ligament (MCL) tears. Following ligament damage, all phases of ligament healing require an adequate blood supply. We hypothesized that the differences in healing properties of the ACL and MCL would reflect their vascular responses to joint injury. This paper examines the long-term changes in blood flow and vascular volume of rabbit knee ligaments after direct injury, and under conditions of chronic joint instability induced by section of the posterior cruciate ligament (PCL).Standardized injuries were surgically induced in adult rabbit knee ligaments: partial MCL transection, partial ACL transection, or complete PCL transection (joint instability). Sixteen weeks later the blood flow and vascular volume of the ACL and MCL were measured and compared to control and sham-operated animals.Direct ligament injury induced significant increases in standardized blood flow and vascular volume of both ACL and MCL after 16 weeks; however, the vascular volume of the ACL was not higher than the control levels in the MCL. We conclude that direct injury to both the anterior cruciate and MCLs induces long-term physiological responses.Joint laxity is a common sequel to PCL injury. Chronic joint laxity failed to induce adaptive vascular responses ill the ACL, while the MCL shows significant amplification of blood supply. Although both MCL and ACL showed increased weight after PCL transection, the lack of a long-term vascular response in the ACL may be a major factor in its the diminished healing potential. (C) 2002 Orthopaedic Research Society. Published by Elsevier Science Ltd. All rights reserved.