The persisting effect of maternal mood in pregnancy on childhood psychopathology
The persisting effect of maternal mood in pregnancy on childhood psychopathology
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DOI：
10.1017/s0954579414000029
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发表时间：
2014-05-01
影响因子：
3.3
通讯作者：
O'Connor, Thomas G.
中科院分区：
文献类型：
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作者：
O'Donnell, Kieran J.;Glover, Vivette;O'Connor, Thomas G.
发育或胎儿编程已成为了解产前暴露对儿童和成人健康和发育的早期和持续影响的主要模型。我们利用一项为期14年的前瞻性研究的力量来研究产前焦虑的持续影响，产前焦虑是发展规划模型中的一个关键候选人，对4岁至13岁的五次测量中的行为和情绪问题症状的影响。这项研究是基于雅芳家长和儿童队列纵向研究，这是一项对英格兰西部大型社区样本（n = 7，944）的前瞻性纵向研究。潜在的混杂因素包括社会心理和产科风险，产后母亲的情绪，父亲的产前和产后情绪，和养育。结果表明，母亲产前焦虑预测持续较高的行为和情绪症状在整个童年没有减少到青春期的影响。在考虑混杂因素后，产前焦虑升高（前15%）与可能的儿童精神障碍风险增加一倍相关，分别为12.31%和6.83%。结果与产前抑郁症相似。这些分析提供了一些迄今为止最有力的证据，产前母亲的情绪有一个直接和持久的影响，她的孩子的精神症状，并支持在子宫内编程假说。
Developmental or fetal programming has emerged as a major model for understanding the early and persisting effects of prenatal exposures on the health and development of the child and adult. We leverage the power of a 14-year prospective study to examine the persisting effects of prenatal anxiety, a key candidate in the developmental programming model, on symptoms of behavioral and emotional problems across five occasions of measurement from age 4 to 13 years. The study is based on the Avon Longitudinal Study of Parents and Children cohort, a prospective, longitudinal study of a large community sample in the west of England (n = 7,944). Potential confounders included psychosocial and obstetric risk, postnatal maternal mood, paternal pre- and postnatal mood, and parenting. Results indicated that maternal prenatal anxiety predicted persistently higher behavioral and emotional symptoms across childhood with no diminishment of effect into adolescence. Elevated prenatal anxiety (top 15%) was associated with a twofold increase in risk of a probable child mental disorder, 12.31% compared with 6.83%, after allowing for confounders. Results were similar with prenatal depression. These analyses provide some of the strongest evidence to date that prenatal maternal mood has a direct and persisting effect on her child's psychiatric symptoms and support an in utero programming hypothesis.