AGE-RELATED INCIDENCE AND OTHER EPIDEMIOLOGIC ASPECTS OF MYELODYSPLASTIC SYNDROMES
AGE-RELATED INCIDENCE AND OTHER EPIDEMIOLOGIC ASPECTS OF MYELODYSPLASTIC SYNDROMES
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DOI：
10.1111/j.1365-2141.1992.tb06430.x
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发表时间：
1992-10-01
影响因子：
6.5
通讯作者：
SCHNEIDER, W
中科院分区：
文献类型：
--
作者：
AUL, C;GATTERMANN, N;SCHNEIDER, W
虽然大多数血液学家认为骨髓增生异常综合征（MDS）的患病率和发病率不断上升，但这些疾病的可靠流行病学数据在很大程度上缺乏。杜塞尔多夫大学的骨髓登记使我们能够评估其他流行病学特征中的MDS发病率，并将其与急性髓系白血病（AML）进行比较。在1975年至1990年登记的18416例不同患者中，确定了584例MDS（3.2%）和506例AML（2.8%）。在研究期间，新诊断的MDS的百分比从1.3%上升到4.5%，而AML没有上升趋势。在所有接受骨髓活检的患者中，60岁以上的患者比例从1975年的41.9%增加到1990年的54.1%。我们发现老年患者的比例和MDS诊断的相对频率之间存在很强的相关性。31例患者（5.3%）由于既往接受过细胞毒性化疗和/或放射治疗各种恶性肿瘤而被归类为继发性MDS。12例患者的职业暴露有机溶剂不能排除。计算年龄特异性发病率，分析仅限于杜塞尔多夫市（575 000居民），因为准确的人口统计数据，为这一人群。在研究期间的最后五年（1986-90），在50-70岁年龄组中，骨髓增生异常综合征比AML更常见（4.9 v1.8/100 000/年）。在70岁以上的患者中，MDS的发病率是AML的3倍多（22.8/10万v6.7/10万）。在该组中，男性MDS的发病率（33.9/100 000）高于女性（18/100 000）。MDS的年发病率（4.1/10万）明显高于AML（2.1/10万），说明MDS是一种较为常见的血液系统肿瘤。近年来发病率的上升可能不是由于病因学因素的变化，但可能反映了医生对老年患者的认识提高和诊断程序的广泛使用。
Although most haematologists perceive a rising prevalence and incidence of myelodysplastic syndromes (MDS), reliable epidemiological data on these disorders are largely lacking. The bone marrow register of the University of Dusseldorf allowed us to assess among other epidemiological features the incidence of MDS, which was compared to that of acute myeloid leukaemia (AML). Among a total of 18 416 different patients registered between 1975 and 1990, 584 cases of MDS (3.2%) and 506 cases of AML (2.8%) were identified. Over the study period, the percentage of newly diagnosed MDS rose from 1.3% to 4.5%, while there was no upward trend for AML. Among all patients undergoing bone marrow biopsy, the proportion of those over 60 years of age increased from 41.9% in 1975 to 54.1% in 1990. We found a strong correlation between the proportion of elderly patients and the relative frequency of MDS diagnoses. Thirty-one patients (5.3%) were classified as a secondary MDS because of previous treatment with cytotoxic chemotherapy and/or irradiation for a variety of malignancies. Twelve patients were identified in whom occupational exposure to organic solvents could not be ruled out.For calculating age-specific incidence rates, the analysis was confined to the town district of Dusseldorf (575 000 inhabitants), because exact demographical data were available for this population. In the last quinquennium of the study period (1986-90), myelodysplastic syndromes were more frequent than AML in the age group 50-70 years (4.9 v 1.8/100 000/year). In patients over 70, the incidence of MDS was more than 3 times that of AML (22.8 v 6.7/100 000). In this group, men had a higher incidence of MDS (33.9/100 000) than women (18/100 000). Crude annual incidence (all age groups) was also higher for MDS (4.1/100 000) than for AML (2.1/100 000) in recent years.We conclude that MDS are relatively common haematological neoplasias. The rising incidence in recent years is probably not due to changes in aetiological factors, but may reflect increased awareness on the part of physicians and extended use of diagnostic procedures in elderly patients.