Reticular Pseudodrusen Are Subretinal Drusenoid Deposits
Reticular Pseudodrusen Are Subretinal Drusenoid Deposits
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DOI：
10.1016/j.ophtha.2009.07.014
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发表时间：
2010-02-01
期刊：
影响因子：
13.7
通讯作者：
Imamura, Yutaka
中科院分区：
文献类型：
--
作者：
Zweifel, Sandrine A.;Spaide, Richard F.;Imamura, Yutaka
目的：描述网状假性玻璃疣，一个潜在的危险因素，为晚期年龄相关性黄斑degeneration.Design：回顾性，观察性病例series.Participants：58眼的33例pseudodrusen（20名女性）。患者通过光谱域光学相干断层扫描（SD OCT）成像，并在近红外图像和SD OCT图像之间进行相关性分析。将假性玻璃疣患者的SD OCT结果与先前报道的视网膜下玻璃疣样沉积物的组织学结果进行比较。组织学标本进行了重新评估的额外知识的临床information.Main结果措施：光谱域光学相干断层扫描和组织学特征的pseudodrusen.Results：33例患者的平均年龄为81.7岁。相关的SD OCT扫描显示在视网膜色素上皮（RPE）上方的颗粒状超反射材料的集合，在主要位于RPE与光感受器的内段和外段之间的边界（IS/OS边界）之间的视网膜下腔中。在更高级的阶段，这种物质形成了突破IS/OS边界的小土丘。与RPE下或脉络膜中观察到的沉积物没有相关性。这些发现是相似的性质，以前报道的视网膜下玻璃疣状存款，这已确定存在膜碎片，未酯化的胆固醇和补体内deposit.Conclusions的组织学特征：假性玻璃疣看到的临床检查可能是视网膜下玻璃疣状存款看到的组织学检查。这个意想不到的位置表明，在与年龄相关的黄斑变性的发展相关的理论中，需要考虑RPE两侧的潜在病理生理机制。财务披露：在参考文献之后可以找到专有或商业披露。Ophthalmology 2010; 117：303-312（C）2010，美国眼科学会。
Purpose: To characterize reticular pseudodrusen, a potential risk factor for late age-related macular degeneration.Design: Retrospective, observational case series.Participants: Fifty-eight eyes of 33 patients with pseudodrusen (20 female).Methods: Consecutive patients with reticular pseudodrusen, diagnosed by their typical appearance and distribution using ophthalmoscopy, the blue channel of color fundus photographs, and near infrared images. The patients were imaged by spectral domain optical coherence tomography (SD OCT), and correlations were made between the near infrared images and the SD OCT images. The SD OCT findings in patients with pseudodrusen were compared with previously reported histologic findings of subretinal drusenoid deposits. The histologic specimens were reevaluated with the additional knowledge of the clinical information.Main Outcome Measures: Spectral domain optical coherence tomography and histologic characteristics of pseudodrusen.Results: The mean age of the 33 patients was 81.7 years. The correlating SD OCT scans showed collections of granular hyperreflective material above the retinal pigment epithelium (RPE), in the subretinal space located primarily between the RPE and the boundary between the inner and outer segments of the photoreceptors (IS/OS boundary). In a more advanced stage, this material formed small mounds that broke through the IS/OS boundary. There were no correlates to the deposits seen under the RPE or in the choroid. These findings were similar in character to previously reported histologic characterization of subretinal drusenoid deposits, which had identified the presence of membranous debris, unesterified cholesterol, and complement within the deposits.Conclusions: Pseudodrusen seen by clinical examination may be subretinal drusenoid deposits seen by histologic examination. This unexpected location suggests that potential pathophysiologic mechanisms on both sides of the RPE need to be taken into account in theories related to the development of age-related macular degeneration.Financial Disclosure(s): Proprietary or commercial disclosure may be found after the references. Ophthalmology 2010; 117: 303-312 (C) 2010 by the American Academy of Ophthalmology.