Temporal properties of retinal ganglion cell responses to local transretinal current stimuli in the frog retina
Temporal properties of retinal ganglion cell responses to local transretinal current stimuli in the frog retina
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DOI：
10.1016/j.visres.2004.08.002
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发表时间：
2005-01-01
期刊：
影响因子：
1.8
通讯作者：
Yagi, T
中科院分区：
文献类型：
--
作者：
Li, LM;Hayashida, Y;Yagi, T
细胞外电流刺激已被用于电生理和临床研究。本研究阐明了局部经视网膜电流刺激引起的青蛙视网膜神经节细胞反应的时间特性。从神经节细胞记录到两类棘波反应。一个人在刺激开始后有一个从1.5到4.5ms的恒定潜伏期，而不考虑刺激参数的差异。另一类人的潜伏期在不同的试验中有所不同，即使在刺激参数相同的情况下，阈值也在3.5到71.5毫秒之间。随着脉冲幅度(50~200MUA)或脉冲持续时间(100~1000mus)的增加，潜伏期缩短，棘波反应数增加。在这两种类型中，相同电荷量的电流刺激对50到200微安的幅度和100到1000微秒的脉冲持续时间都有相似的潜伏期。(C)2004爱思唯尔有限公司。保留所有权利。
Extracellular current stimuli have been used in both electrophysiological and clinical studies. The present study elucidates the temporal properties of the frog retinal ganglion cell response induced by local transretinal current stimuli. Two classes of spike response were recorded from the ganglion cell. One had a constant latency ranging from 1.5 to 4.5 ms after the onset of the stimulus regardless of differences in stimulus parameters. Another class had a latency that varied from trial to trial between 3.5 and 71.5 ms at the threshold even when stimulus parameters were identical. The latency became shorter and the number of spike responses increased as the charge applied via the stimulus pulse was increased by increasing the amplitude (from 50 to 200 muA) or the pulse duration (from 100 to 1000 mus). In both classes, the current stimuli with the same amount of charge induced responses of a similar latency for amplitudes between 50 and 200 muA and for pulse durations between 100 and 1000 mus. (C) 2004 Elsevier Ltd. All rights reserved.