Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder.
Altered resting-state functional connectivity of the insula in young adults with Internet gaming disorder.
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DOI：
10.1111/adb.12247
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发表时间：
2016-05
影响因子：
3.4
通讯作者：
Fang XY
中科院分区：
文献类型：
--
作者：
Zhang JT;Yao YW;Li CS;Zang YF;Shen ZJ;Liu L;Wang LJ;Liu B;Fang XY
脑岛与显著性处理、渴望和内感受有关，所有这些对药物和行为成瘾的临床表现都至关重要。在这项fMRI研究中，我们检测了74名患有网络游戏障碍（IGD）的年轻成年人和41名年龄和性别匹配的健康对照组（hc）的脑岛静息状态功能连接（rsFC）及其与网络游戏特征的关系。与hc相比，IGD受试者（IGD）在脑岛前部和包括前扣带皮层（ACC）、壳核、角回和前额叶在内的区域网络之间表现出增强的rsFC，这些区域涉及显著性、渴望、自我监控和注意力。igd在脑岛后部与中枢后回、中央前回、辅助运动区和颞上回（STG）之间的rsFC也明显增强，这些区域涉及内感受、运动控制和听觉加工。此外，IGD的严重程度与前岛与角回、STG、后岛与STG之间的连通性呈正相关，网络游戏的持续时间与前岛与ACC之间的连通性呈正相关。这些发现强调了脑岛在IGD核心症状表现中的关键作用，以及在IGD中分别检查前脑岛和后脑岛功能异常的重要性。
The insula has been implicated in salience processing, craving, and interoception, all of which are critical to the clinical manifestations of drug and behavioral addiction. In this fMRI study, we examined resting-state functional connectivity (rsFC) of the insula and its association with Internet gaming characteristics in 74 young adults with Internet gaming disorder (IGD) and 41 age and gender matched healthy control subjects (HCs). In comparison to HCs, IGD subjects (IGDs) exhibited enhanced rsFC between the anterior insula and a network of regions including anterior cingulate cortex (ACC), putamen, angular gyrus, and precuneous, which are involved in salience, craving, self-monitoring, and attention. IGDs also demonstrated significantly stronger rsFC between the posterior insula and postcentral gyrus, precentral gyrus, supplemental motor area, and superior temporal gyrus (STG), which are involved in interoception, movement control, and auditory processing. Furthermore, IGD severity was positively associated with connectivity between the anterior insula and angular gyrus, and STG, and with connectivity between the posterior insula and STG. Duration of Internet gaming was positively associated with connectivity between the anterior insula and ACC. These findings highlight a key role of the insula in manifestation of the core symptoms of IGD and the importance to examine functional abnormalities of the anterior and posterior insula separately in IGDs.