CA2+ PERMEABILITY OF UNEDITED AND EDITED VERSIONS OF THE KAINATE SELECTIVE GLUTAMATE RECEPTOR GLUR6
CA2+ PERMEABILITY OF UNEDITED AND EDITED VERSIONS OF THE KAINATE SELECTIVE GLUTAMATE RECEPTOR GLUR6
复制标题
DOI：
10.1073/pnas.90.2.755
复制
发表时间：
1993-01-15
影响因子：
11.1
通讯作者：
HEINEMANN, SF
中科院分区：
文献类型：
--
作者：
EGEBJERG, J;HEINEMANN, SF
盐选择性谷氨酸受体GluR6的Ca2+通透性取决于RNA（或DNA）的编辑。未编辑的GluR6 GluR6Q在621位点（Q/R位点）编码谷氨酰胺，Ca2+/单价离子通透率为1.2，而编辑的GluR6 GluR6R在621位点编码精氨酸，通透率为0.47。盐激活GluR6受体产生由细胞外钙离子调节的电流。其他二价离子的通透率表明Q/R位点不是二价离子通透性的唯一决定因素。受体的编辑水平将决定Ca2+通过GluR6受体通道的内流，因此可能调节突触活动。
The Ca2+ permeability of the kainate selective glutamate receptor GluR6 depends on the editing of the RNA (or DNA). The unedited version of GluR6, GluR6Q, encodes a glutamine at position 621 (Q/R site) and exhibits a Ca2+/monovalent ion permeability ratio of 1.2, while the edited version of GluR6, GluR6R, encodes an arginine at position 621 and exhibits a permeability ratio of 0.47. Kainate activation of the GluR6 receptor results in currents that are modulated by extracellular calcium ions. Permeability ratios of other divalent ions indicate that the Q/R site is not the only determinant for divalent ion permeability. The level of editing of the receptor will determine the Ca2+ influx through the GluR6 receptor channels and, consequently, may modulate the synaptic activity.