Are UHR patients who present with hallucinations alone at lower risk of transition to psychosis?
Are UHR patients who present with hallucinations alone at lower risk of transition to psychosis?
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DOI：
10.1016/j.psychres.2015.05.085
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发表时间：
2016-01-30
影响因子：
11.3
通讯作者：
Thompson, Andrew
中科院分区：
文献类型：
--
作者：
O'Connor, Karen;Nelson, Barnaby;Thompson, Andrew
本研究的目的是调查在确定为 UHR 时仅出现幻觉的超高风险精神病 (UHR) 患者是否比出现幻觉以外的症状或出现幻觉加其他症状的 UHR 患者转变为精神病的风险更低。我们的主要数据集是对 UHR 患者 (N=118) 的回顾性“病例对照”研究。第二个独立数据集是 UHR 患者的长期纵向随访研究 (N=416)。我们使用对数秩检验和 Cox 回归进行生存分析，以研究症状变量与向精神病转变之间的关系。基线时仅出现幻觉与向精神病转变的风险降低没有显着相关性。在病例对照研究中，在没有任何思维障碍的情况下出现幻觉，在没有滥用药物的情况下出现幻视，与转化为精神病的风险降低相关。在纵向随访数据集中，在没有情感或情绪障碍的情况下发现的知觉障碍与转变为精神病的风险增加相关。 (C) 2015 Elsevier Ireland Ltd. 保留所有权利。
The aim of this study was to investigate whether Ultra High Risk for psychosis (UHR) patients who present with hallucinations alone at identification as UHR are at lower risk of transition to psychosis than UHR patients who present with symptoms other than hallucinations or hallucinations plus other symptoms.Our primary dataset was a retrospective "case-control" study of UHR patients (N=118). The second, independent dataset was a long-term longitudinal follow up study of UHR patients (N=416). We performed a survival analysis using Log-rank test and Cox regression to investigate the relationship between symptom variables and transition to a psychotic disorder.Hallucinations alone at baseline were not significantly associated with a reduced risk of transition to psychosis. In the case control study the presence of hallucinations when found in the absence of any thought disorder and visual hallucinations in the absence of substance misuse was associated with a reduced risk of transition to psychosis. In the longitudinal follow-up dataset perceptual disturbance found in the absence of a disorder of affect or emotion was associated with an increased risk of transition to psychosis. (C) 2015 Elsevier Ireland Ltd. All rights reserved.