OBESITY AND BENIGN PROSTATIC HYPERPLASIA
OBESITY AND BENIGN PROSTATIC HYPERPLASIA
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DOI：
10.1093/oxfordjournals.aje.a117206
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发表时间：
1994-12-01
影响因子：
5
通讯作者：
WILLETT, WC
中科院分区：
文献类型：
--
作者：
GIOVANNUCCI, E;RIMM, EB;WILLETT, WC
腹部肥胖增加雌激素与雄激素的比例，并可能增加交感神经活动，这两种假设影响良性前列腺增生的发展和尿路梗阻症状的严重程度。在1986年和1987年，40-75岁的男性参与了卫生专业人员随访研究，他们没有预先诊断出癌症或直肠癌切除术，提供了体重，身高，腰围和臀围的数据。随访这些男性直到1992年1月因良性前列腺增生行前列腺切除术的发生率。此外，在1992年的一份问卷调查中，对尿路梗阻症状的频率和严重程度进行了评估。在25,892名提供手术和症状完整信息的男性中，837名男性接受了良性前列腺增生手术，2,581名未接受手术的男性报告了频繁的泌尿系统症状。在校正年龄、吸烟和体重指数后，腹型肥胖与直肠癌切除术相关（腰围大于或等于43英寸（109 cm）的患者与腰围小于或等于43英寸（109 cm）的患者相比，比值比（OR）= 2.38，95%置信区间（CI）为1.42-3.99）。
Abdominal obesity increases the estrogen-to-androgen ratio and may increase sympathetic nervous activity, both hypothesized to influence the development of benign prostatic hyperplasia and the severity of urinary obstructive symptoms. In 1986 and 1987, men aged 40-75 years who were participants in the Health Professionals Follow-up Study and who were without prior diagnosis of cancer or prostatectomy provided data on weight, height, and waist and hip circumferences. The men were followed for incidence of prostatectomy for benign prostatic hyperplasia up to January 1992. In addition, the frequency and severity of symptoms of urinary obstruction were assessed among respondents to a questionnaire in 1992. Among 25,892 men who provided complete information for both surgery and symptoms, 837 men had surgery for benign prostatic hyperplasia, and 2,581 of those without surgery reported frequent urinary symptoms. After adjustment for age, smoking, and body mass index, abdominal obesity was related to prostatectomy (odds ratio (OR) = 2.38, 95% confidence interval (Cl) 1.42-3.99, for those with a waist circumference greater than or equal to 43 inches (109 cm) relative to those with a waist circumference