Long-chain monounsaturated Fatty acids and incidence of congestive heart failure in 2 prospective cohorts.
Long-chain monounsaturated Fatty acids and incidence of congestive heart failure in 2 prospective cohorts.
复制标题
长链单不饱和脂肪酸和2个前瞻性队列中充血性心力衰竭的发生率。
DOI：
10.1161/circulationaha.112.001197
复制
发表时间：
2013-04-09
期刊：
影响因子：
37.8
通讯作者：
Mozaffarian D
中科院分区：
文献类型：
--
作者：
Imamura F;Lemaitre RN;King IB;Song X;Steffen LM;Folsom AR;Siscovick DS;Mozaffarian D
几十年的动物实验表明，饮食中的长链单不饱和脂肪酸（LCMUFA）会导致心脏毒性，例如，加拿大从油菜籽中开发了低芥酸菜籽油（Canola）。然而，LCMUFA在人类和当代饮食来源中的潜在心脏毒性尚不清楚。我们前瞻性地研究了血浆磷脂LCMUFA（20：1、22：1和24：1），暴露的客观生物标志物，以及两个独立队列中充血性心力衰竭（CHF）的发生率：3，694名老年人（平均年龄=75.2±5.2岁）（CHS，1992-2006）和明尼苏达州社区动脉粥样硬化风险研究子队列（ARIC，1987-2008）中的3，577名中年成人（平均年龄=54.1±5.8岁）。我们进一步研究了CHS和ARIC中循环LCMUFA的饮食相关性，以及2003-2010年国家健康和营养调查（NHANES）中LCMUFA的美国饮食来源。在CHS中，39，238人年中发生了997起CHF事件;在ARIC中，64，438人年中发生了330起事件。多变量校正后，在CHS和ARIC中，较高水平的22：1和24：1与较高的CHF事件呈正相关：风险比（95%置信区间）=1.34对于22：1的最高与最低五分位数，分别为（1.02-1.76）和1.57（1.11-2.23）;对于24：1，分别为1.75（1.23-2.50）和1.92（1.22-3.03）（P趋势均≤0.03）。与CHS和ARIC中循环LCMUFA相关的各种食物，与NHANES中LCMUFA的食物来源一致，包括鱼，家禽，肉类，全谷物和芥末。在两个独立队列中，较高的循环水平（22：1和24：1）以及明显不同的饮食来源与CHF事件相关，表明LCMUFA可能对人体具有心脏毒性。
Decades-old animal experiments suggested dietary long-chain monounsaturated fatty acids (LCMUFA) caused cardiotoxicity, leading, for example, Canada to develop Canadian-oil-low-in-erucic-acid (Canola) from rapeseed. However, potential cardiotoxicity in humans and contemporary dietary sources of LCMUFA are unknown. We prospectively investigated associations of plasma phospholipid LCMUFA (20:1, 22:1, and 24:1), objective biomarkers of exposure, with incidence congestive heart failure (CHF) in two independent cohorts: 3,694 older adults (mean age=75.2±5.2 years) in the Cardiovascular Health Study (CHS, 1992–2006), and 3,577 middle-aged adults (mean age=54.1±5.8 years) in the Atherosclerosis Risk in Communities Study Minnesota subcohort (ARIC, 1987–2008). We further examined dietary correlates of circulating LCMUFA in CHS and ARIC, and US dietary sources of LCMUFA in the 2003–2010 National Health and Nutrition Examination Survey (NHANES). In CHS, 997 CHF events occurred during 39,238 person-years; and in ARIC, 330 events during 64,438 person-years. After multivariable-adjustment, higher levels of 22:1 and 24:1 were positively associated with greater incident CHF in both CHS and ARIC: hazard ratios (95% confidence interval)=1.34 (1.02–1.76) and 1.57 (1.11–2.23) for highest vs. lowest quintiles of 22:1, respectively; and 1.75 (1.23–2.50) and 1.92 (1.22–3.03) for 24:1, respectively (P-trend≤0.03 each). A variety of foods related to circulating LCMUFA in CHS and ARIC, consistent with food sources of LCMUFA in NHANES, including fish, poultry, meats, whole grains, and mustard. Higher circulating levels of 22:1 and 24:1, with apparently diverse dietary sources, were associated with incident CHF in two independent cohorts, suggesting possible cardiotoxicity of LCMUFA in humans.