Coronary calcium as a predictor of coronary events in four racial or ethnic groups
Coronary calcium as a predictor of coronary events in four racial or ethnic groups
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DOI：
10.1056/nejmoa072100
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发表时间：
2008-03-27
影响因子：
158.5
通讯作者：
Kronmal, Richard A.
中科院分区：
文献类型：
--
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
背景资料：在白色人群中，冠状动脉钙化的计算机断层扫描测量可独立于传统的冠状动脉危险因素预测冠心病。然而，目前尚不清楚是否冠状动脉钙预测冠心病在其他种族或ethnics.Methods：我们收集的危险因素的数据，并进行扫描冠状动脉钙在基于人口的样本6722名男性和女性，其中38.6%是白色，27.6%是黑人，21.9%是西班牙裔，11.9%是中国人。研究对象没有临床心血管疾病在进入和随访的中位数为3.8 years.Results：有162冠状动脉事件，其中89个主要事件（心肌梗死或冠心病死亡）。与无冠状动脉钙化的受试者相比，冠状动脉钙化评分在101 - 300之间的受试者发生冠状动脉事件的校正风险增加了7.73倍，评分高于300的受试者增加了9.67倍（P
Background: In white populations, computed tomographic measurements of coronary-artery calcium predict coronary heart disease independently of traditional coronary risk factors. However, it is not known whether coronary-artery calcium predicts coronary heart disease in other racial or ethnic groups.Methods: We collected data on risk factors and performed scanning for coronary calcium in a population-based sample of 6722 men and women, of whom 38.6% were white, 27.6% were black, 21.9% were Hispanic, and 11.9% were Chinese. The study subjects had no clinical cardiovascular disease at entry and were followed for a median of 3.8 years.Results: There were 162 coronary events, of which 89 were major events (myocardial infarction or death from coronary heart disease). In comparison with participants with no coronary calcium, the adjusted risk of a coronary event was increased by a factor of 7.73 among participants with coronary calcium scores between 101 and 300 and by a factor of 9.67 among participants with scores above 300 (P