Tail and Head Group Interactions in Phospholipid Monolayers
Tail and Head Group Interactions in Phospholipid Monolayers
复制标题
磷脂单层中尾部和头部基团的相互作用
DOI：
10.1006/jcis.1996.0101
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
H. Möhwald
中科院分区：
文献类型：
--
作者：
H. Baltes;M. Schwendler;C. Helm;H. Möhwald
摘要利用x射线反射和热力学测量研究了磷脂1,2-二十六基-sn-甘油-3-磷酸胆碱及其衍生物的有序/无序跃迁。我们发现，增加磷酸基和疏水链之间的环氧乙烷间隔（0到3个EO基团）的长度(i)会引起主跃迁的轻微移动，（ii）减少头基团对链晶格的影响，（iii）增加头基团长度并促进其水合作用。对于有序相的DH(EO)3PC，我们发现小磷酸基团（这是x射线反射率的主要对比源）均匀分布在头基区域内。在流体相中，磷酸基团优先朝向空气/水界面。
Abstract The order/disorder transition of the phospholipid 1,2-dihexadecyl-sn-glycero-3-phosphocholine and its derivatives was studied by X-ray reflection and thermodynamic measurements. We find that increasing the length of an ethylene oxide spacer (zero to three EO groups) between the phosphate group and the hydrophobic chains (i) induces a slight shift of the main transition, (ii) reduces the influence of the head groups on the chain lattice, and (iii) increases the head group length and promotes its hydration. For DH(EO)3PC in the ordered phase we find that the small phosphate groups (which are the main source of contrast in X-ray reflectivity) are homogeneously distributed within the head group region. In the fluid phase the phosphate groups are preferentially oriented toward the air/water interface.