Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture.
Protective effect of ligustrazine on lumbar intervertebral disc degeneration of rats induced by prolonged upright posture.
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川芎嗪对长期直立大鼠腰椎间盘退变的保护作用
DOI：
10.1155/2014/508461
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Wang YJ
中科院分区：
文献类型：
--
作者：
Liang QQ;Ding DF;Xi ZJ;Chen Y;Li CG;Liu SF;Lu S;Zhao YJ;Shi Q;Wang YJ
大多数慢性腰痛是腰椎间盘退变的结果。据报道，川芎中的生物碱川芎嗪能够止痛、抑制炎症、治疗骨关节炎，并对软骨和软骨细胞具有保护作用。因此，我们询问川芎嗪是否可以减少椎间盘退变。为了确定川芎嗪对椎间盘退变的影响，我们应用了大鼠模型。长期直立姿势诱发大鼠椎间盘退变。我们发现用川芎嗪预处理1个月可以恢复退变椎间盘的结构扭曲；抑制 X 型胶原、基质金属蛋白酶 (MMP)-13 和 MMP3 的表达； II 型胶原蛋白上调；并降低 IL-1β、环氧合酶 (COX)-2 和诱导型一氧化氮合酶 (iNOS) 的表达。总之，川芎嗪是治疗腰椎间盘退变疾病的有前途的药物。
Most chronic low back pain is the result of degeneration of the lumbar intervertebral disc. Ligustrazine, an alkaloid from Chuanxiong, reportedly is able to relieve pain, suppress inflammation, and treat osteoarthritis and it has the protective effect on cartilage and chondrocytes. Therefore, we asked whether ligustrazine could reduce intervertebral disc degeneration. To determine the effect of ligustrazine on disc degeneration, we applied a rat model. The intervertebral disc degeneration of the rats was induced by prolonged upright posture. We found that pretreatment with ligustrazine for 1 month recovered the structural distortion of the degenerative disc; inhibited the expression of type X collagen, matrix metalloproteinase (MMP)-13, and MMP3; upregulated type II collagen; and decreased IL-1β, cyclooxygenase (COX)-2, and inducible nitric oxide synthase (iNOS) expression. In conclusion, ligustrazine is a promising agent for treating lumbar intervertebral disc degeneration disease.