Pleiotropic mechanisms of virus survival and persistence.

Pleiotropic mechanisms of virus survival and persistence.
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DOI:
10.1016/j.tripleo.2005.03.017
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发表时间:
2005-08
期刊:
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
影响因子:
--
通讯作者:
Miller CS
Miller CS
中科院分区:
其他
文献类型:
--
作者:
Miller CS

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病毒是非常有效的传染媒介,几个世纪以来一直与引起人类疾病有关。这些病原体继续以孤立病例、流行病和大流行病的形式从一种生命形式传播到另一种生命形式。每次感染都需要进入易感宿主,复制和逃避免疫系统。病毒是成功的病原体,因为它们针对特定细胞进行攻击,利用细胞机制,并且有效地规避和/或抑制生存所需的关键细胞事件。本文回顾了过去50年来人类病毒学的一些进展,强调了有助于病毒存活和持久性的机制。
Viruses are enormously efficient infectious agents that have been implicated in causing human disease for centuries. Transmission of these pathogens continues to be from one life form to another in the form of isolated cases, epidemics, and pandemics. Each infection requires entry into a susceptible host, replication, and evasion of the immune system. Viruses are successful pathogens because they target specific cells for their attack, exploit the cellular machinery, and are efficient in circumventing and/or inhibiting key cellular events required of survival. This article reviews some of the advances that have taken place in human virology in the past 50 years, emphasizing mechanisms that contribute to, and are involved with, virus survival and persistence.
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