Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.
Female sterile mutations on the second chromosome of Drosophila melanogaster. II. Mutations blocking oogenesis or altering egg morphology.
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果蝇第二条染色体上的雌性不育突变。
DOI：
10.1093/genetics/129.4.1119
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发表时间：
1991
期刊：
影响因子：
3.3
通讯作者：
Wieschaus,E
中科院分区：
文献类型：
--
作者：
Schüpbach,T;Wieschaus,E
在黑腹果蝇第二条染色体上隐性雌性不育突变的诱变筛选中，分离出528个株系，这些株系允许纯合雌性存活但导致不育。在这些品系中的62个中，卵子发生的早期阶段受到影响，并且这些雌性通常不产卵。在333个品系中，卵子发生明显正常地进行到卵子发生的第8阶段，但在卵子发生的后期阶段，形态缺陷往往变得明显，并且在这些雌性产生的缺陷卵中可见，而133个品系产下的卵形态正常，但不支持正常的胚胎发育。在这些品系中，341个已被遗传表征并在第二染色体上限定了总共140个基因座。并非所有基因座都是卵子发生所特有的。从获得的数字，我们估计，果蝇的第二条染色体包含约13个基因座，是相对特定的早期卵子发生，70个基因座，特别是在中期到晚期卵子发生所需的，和大约30个母亲的影响致死。
In mutagenesis screens for recessive female sterile mutations on the second chromosome of Drosophila melanogaster 528 lines were isolated which allow the homozygous females to survive but cause sterility. In 62 of these lines early stages of oogenesis are affected, and these females usually do not lay any eggs. In 333 lines oogenesis proceeds apparently normally to stage 8 of oogenesis, but morphological defects become often apparent during later stages of oogenesis, and are visible in the defective eggs produced by these females whereas 133 lay eggs that appear morphologically normal, but do not support normal embryonic development. Of the lines 341 have been genetically characterized and define a total of 140 loci on the second chromosome. Not all the loci are specific for oogenesis. From the numbers obtained we estimate that the second chromosome of Drosophila contains about 13 loci that are relatively specific for early oogenesis, 70 loci that are specifically required in mid to late oogenesis, and around 30 maternal-effect lethals.