Symmetry, stability, and dynamics of multidomain and multicomponent protein systems
Symmetry, stability, and dynamics of multidomain and multicomponent protein systems
复制标题
DOI：
10.1073/pnas.93.25.14243
复制
发表时间：
1996-12-10
影响因子：
11.1
通讯作者：
Srinivasan, N
中科院分区：
文献类型：
--
作者：
Blundell, TL;Srinivasan, N
对称性在许多生物系统中普遍存在。在这里，我们讨论对称性在结构分子生物学中的作用的代表性例子。点群对称性在许多蛋白质寡聚体中被观察到，其三维原子结构已被X射线晶体学阐明。近似对称性也发生在多结构域蛋白质中。对称性通常赋予分子系统稳定性，并导致经济地使用基本组分来构建大分子结构。对称性也与协同性有关。在某些系统中，对动力学函数来说，来自完全对称性的轻微扰动可能是必不可少的。
Symmetry is commonly observed in many biological systems. Here we discuss representative examples of the role of symmetry in structural molecular biology. Point group symmetries are observed in many protein oligomers whose three-dimensional atomic structures have been elucidated by x-ray crystallography. Approximate symmetry also occurs in multidomain proteins. Symmetry often confers stability on the molecular system and results in economical usage of basic components to build the macromolecular structure. Symmetry is also associated with cooperativity. Mild perturbation from perfect symmetry mag be essential in some systems for dynamic functions.