Risk factors for death among tuberculosis cases: analysis of European surveillance data
Risk factors for death among tuberculosis cases: analysis of European surveillance data
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DOI：
10.1183/09031936.00131107
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发表时间：
2008-06-01
影响因子：
24.3
通讯作者：
Falzon, D.
中科院分区：
文献类型：
--
作者：
Lefebvre, N.;Falzon, D.
欧洲联盟（EU）结核病患者的死亡率仍然很高（总体为8%）。本研究的目的是量化与人口统计学和临床因素相关的死亡风险。利用逻辑回归分析了2002-2004年期间15个欧盟国家通报的39,566名结核病患者的病例数据。研究发现，年龄增长和对异烟肼和利福平的耐药性是死亡的最强决定因素，而男性、欧洲血统、肺部疾病部位和既往抗结核治疗是较弱的预测因素。风险因报告国家而异，可能反映了患者概况、报告做法和规划有效性的差异。总之，早期的怀疑、诊断和治疗可以减少死亡，特别是老年人的死亡。需要特别注意避免耐多药结核病的发展和传播。
The proportion of tuberculosis (TB) patients in the European Union (EU) who die remains high (8% overall). The aim of the present study was to quantify the risk of dying associated with demographic and clinical factors.Case-based data on 39,566 TB patients notified by 15 EU countries during 2002-2004 were analysed using logistic regression.It was observed that advancing age and resistance to isoniazid and rifampicin were the strongest determinants of death, while male sex, European origin, pulmonary site of disease and previous anti-TB treatment were weaker predictors. Risk varied between reporting countries, presumably reflecting differences in patient profiles, reporting practices and programme effectiveness.In conclusion, earlier suspicion, diagnosis and treatment may reduce deaths, particularly among the elderly. Special attention is needed to avert the development and transmission of multidrug-resistant tuberculosis.