Reflex pathways from group II muscle afferents
Reflex pathways from group II muscle afferents
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II 组肌肉传入的反射通路
DOI：
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发表时间：
2004
影响因子：
2
通讯作者：
E. Schomburg
中科院分区：
文献类型：
--
作者：
A. Lundberg;K. Malmgren;E. Schomburg
通过对运动神经元至膝屈肌和伸踝肌的细胞内记录，重新研究了电刺激下腰猫第二类肌肉传入所引起的神经间反射反应。ECCLES和Lundberg(1959)的结果得到了证实和推广。II组兴奋的屈肌和伸肌向屈肌、II组抑制的屈肌和伸肌运动神经元广泛汇聚。描述了不同神经在作用上的一些定量差异。潜伏期测量表明，兴奋性神经元间通路中的最小联系是双突触，而抑制性通路中的最小联系是三突触。双突触II组EPSP存在于14%的踝伸肌运动神经元中，但在未麻醉的高脊椎猫中更为常见(Wilson和Kato 1965)。从这些结果和屈肌的相应结果(Holmqvist和Lundberg，1961)推测，次级传入除了弱的单突触连接外(Kirkwood和Sears，1975)，对屈肌和伸肌运动神经元都有双突触兴奋通路和三突触抑制通路。作者认为，麻醉下脊髓猫屈肌反射模式的第II类活动是由于抑制了到屈肌运动神经元的抑制通路和到伸肌运动神经元的兴奋通路。在一些踝伸肌运动神经元中，双突触II类EPSP与来自FRA的IPSP(包括II类和III类肌肉传入)合并出现。这些II组EPSP可能是由II组神经元间通路介导的，而III组肌肉传入很少或根本没有输入，但可能来自肌外受体。其他踝伸肌运动神经元II组与III组肌肉传入、皮肤传入和关节传入的EPSPS联合使用。据推测，这些II类EPSP是由FRA的神经元间通路介导的，该通路还提供神经元间通路，抑制伸肌或/和屈肌运动神经元，兴奋屈肌，如Eccle和Lundberg(1959)和Holmqvist和Lundberg(1961)所假设的那样。
SummaryThe interneuronally mediated reflex actions evoked by electrical stimulation of group II muscle afferents in low spinal cats have been reinvestigated with intracellular recording from motoneurones to knee flexors and ankle extensors. The results of Eccles and Lundberg (1959) have been confirmed and extended. There was wide convergence from flexors and extensors of group II excitation to flexor and group II inhibition to extensor motoneurones. Some quantitative differences in the effect from the different nerves are described. Latency measurements suggest that the minimal linkage is disynaptic in the excitatory interneuronal pathways and trisynaptic in the inhibitory pathways. Disynaptic group II EPSPs were found in 14% of the ankle extensor motoneurones but were much more common in unanaesthetized high spinal cats (Wilson and Kato 1965). From these results and corresponding ones on flexors (Holmqvist and Lundberg 1961) it is postulated that secondary afferents in addition to the weak monosynaptic connexions (Kirkwood and Sears 1975) have disynaptic excitatory pathways and trisynaptic inhibitory pathways to both flexor and extensor motoneurones. It is proposed that the group II actions of the flexor reflex pattern characterizing the anaesthetized low spinal cat are due to suppression of the inhibitory pathway to flexor motoneurones and the excitatory pathway to extensor motoneurones. In some ankle extensor motoneurones the disynaptic group II EPSPs occurred in combination with IPSPs from the FRA (including group II and III muscle afferents). The possibility is considered that these group II EPSPs are mediated by an interneuronal group II pathway with little or no input from group III muscle afferents but probably from extramuscular receptors. In other ankle extensor motoneurones group II EPSPs were combined with EPSPs from group III muscle afferents, cutaneous afferents and joint afferents. It is postulated that these group II EPSPs are mediated by an interneuronal pathway from the FRA which also supply interneuronal pathways giving inhibition to extensor or/and flexor motoneurones and excitation to flexors as postulated by Eccles and Lundberg (1959) and Holmqvist and Lundberg (1961).
猫中单个纺锤体 II 组传入神经向类型识别的内侧腓肠肌运动神经元的单突触投射。
影响因子：
2.5
作者：
Munson,JB;Sypert,GW;Zengel,JE;Lofton,SA;Fleshman,JW
通讯作者：
Fleshman,JW