Green tea intake is associated with urinary estrogen profiles in Japanese-American women.
Green tea intake is associated with urinary estrogen profiles in Japanese-American women.
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DOI：
10.1186/1475-2891-12-25
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发表时间：
2013-02-15
影响因子：
5.4
通讯作者：
Ziegler RG
中科院分区：
文献类型：
--
作者：
Fuhrman BJ;Pfeiffer RM;Wu AH;Xu X;Keefer LK;Veenstra TD;Ziegler RG
摄入绿色茶可以降低患乳腺癌的风险;这种饮料中的多酚可以影响代谢雌激素的酶，这是乳腺癌病因学中已知的致病因素。我们研究了健康日裔美国妇女的横断面样本中绿色茶摄入量（<1次/周，每周1-6次，或每周7次以上）与尿雌激素和雌激素代谢物（联合EM）的关系，包括119名处于黄体期的绝经前妇女和72名绝经后妇女。我们将稳健的回归模型拟合到每个对数转换的EM浓度（皮摩尔/mg肌酐），调整年龄和研究中心。在绝经前妇女中，摄入绿色茶与较低的黄体总EM（P趋势= 0.01）和较低的尿16-途径EM（P趋势= 0.01）相关。在绝经后妇女中，每天饮用绿色茶的妇女与每周饮用<1次的妇女相比，尿雌酮和雌二醇约低20%和40%（P趋势分别= 0.01和0.05）。调整潜在的混杂因素（初潮年龄，产次/第一胎年龄，体重指数，亚洲出生地，大豆）并没有改变这些协会。研究结果表明，摄入绿色茶可能会改变雌激素代谢或结合，并以这种方式可能会影响乳腺癌的风险。
Intake of green tea may reduce the risk of breast cancer; polyphenols in this drink can influence enzymes that metabolize estrogens, known causal factors in breast cancer etiology. We examined the associations of green tea intake (<1 time/week, 1-6 times weekly, or 7+ times weekly) with urinary estrogens and estrogen metabolites (jointly EM) in a cross-sectional sample of healthy Japanese American women, including 119 premenopausal women in luteal phase and 72 postmenopausal women. We fit robust regression models to each log-transformed EM concentration (picomoles per mg creatinine), adjusting for age and study center. In premenopausal women, intake of green tea was associated with lower luteal total EM (P trend = 0.01) and lower urinary 16-pathway EM (P trend = 0.01). In postmenopausal women, urinary estrone and estradiol were approximately 20% and 40% lower (P trend = 0.01 and 0.05, respectively) in women drinking green tea daily compared to those drinking <1 time/week. Adjustment for potential confounders (age at menarche, parity/age at first birth, body mass index, Asian birthplace, soy) did not change these associations. Findings suggest that intake of green tea may modify estrogen metabolism or conjugation and in this way may influence breast cancer risk.
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DOI：
10.1158/1055-9965.epi-09-0591
发表时间：
2009-11
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Eliassen AH;Ziegler RG;Rosner B;Veenstra TD;Roman JM;Xu X;Hankinson SE
通讯作者：
Hankinson SE
影响因子：
3.6
作者：
Oba, Shino;Nagata, Chisato;Shimizu, Hiroyuki
通讯作者：
Shimizu, Hiroyuki
影响因子：
3.3
作者：
James, Rebecca E.;Lukanova, Annekatrin;Kaaks, Rudolf
通讯作者：
Kaaks, Rudolf
影响因子：
6.1
作者：
Monteiro, Rosario;Azevedo, Isabel;Calhau, Conceicao
通讯作者：
Calhau, Conceicao
影响因子：
3.8
作者：
Fuhrman, Barbara J.;Brinton, Louise A.;Gierach, Gretchen L.
通讯作者：
Gierach, Gretchen L.