Array CGH technologies and their applications to cancer genomes
Array CGH technologies and their applications to cancer genomes
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DOI：
10.1007/s10577-005-2168-x
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发表时间：
2005-01-01
影响因子：
2.6
通讯作者：
Lam, WL
中科院分区：
文献类型：
--
作者：
Davies, JJ;Wilson, IM;Lam, WL
癌症是一种以基因组不稳定为特征的疾病。比较基因组杂交（CGH）是一种旨在检测片段基因组改变的技术。基于阵列的 CGH 技术的最新进展使我们能够以前所未有的细节检查染色体区域，彻底改变了我们对肿瘤基因组的理解。目前已经开发了许多基于阵列的技术，旨在提高 CGH 的分辨率，使研究人员能够细化和定义基因组中可能导致癌症的区域，并促进基因的快速发现。本文回顾了各种阵列 CGH 平台及其在癌症基因组研究中的用途。此外，还讨论了高分辨率分析的必要性以及研究早期疾病以发现可能导致癌症进展和病因的遗传改变的重要性。
Cancer is a disease characterized by genomic instability. Comparative genomic hybridization (CGH) is a technique designed for detecting segmental genomic alterations. Recent advances in array-based CGH technology have enabled examination of chromosomal regions in unprecedented detail, revolutionizing our understanding of tumour genomes. A number of array-based technologies have been developed, aiming to improve the resolution of CGH, enabling researchers to refine and define regions in the genome that may be causal to cancer, and facilitating gene discovery at a rapid rate. This article reviews the various array CGH platforms and their use in the study of cancer genomes. In addition, the need for high-resolution analysis is discussed as well as the importance of studying early-stage disease to discover genetic alterations that may be causal to cancer progression and aetiology.