Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis
Investigation of SEN virus infection in patients with cryptogenic acute liver failure, hepatitis-associated aplastic anemia, or acute and chronic non-A-E hepatitis
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DOI：
10.1086/379216
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发表时间：
2003-11-15
影响因子：
6.4
通讯作者：
Alter, HJ
中科院分区：
文献类型：
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作者：
Umemura, T;Tanaka, E;Alter, HJ
SEN 病毒 (SENV) 已初步被证实与输血相关的非甲戊型肝炎有关。我们调查了 SENV 在其他情况下不明原因肝炎中的作用。使用聚合酶链式反应扩增检测 1706 名患者和对照受试者的 2 种 SENV 变异（SENV-D 和 SENV-H）。 248 名急性或慢性非甲戊型肝炎患者中检测到 SENV 54 例（22%），26 名肝炎相关再生障碍性贫血患者中检测到 9 例（35%），17 名隐源性急性肝衰竭患者中检测到 0 例 SENV，而 621 名肝病对照受试者中检测到 150 例（24%），794 名健康对照受试者中检测到 76 例（10%）。当控制地理区域时，病例和对照受试者中 SENV 的患病率没有显着差异。急性或慢性甲型、乙型或丙型肝炎的严重程度不受共存 SENV 感染的影响。无法证明 SENV 在隐源性肝炎中的病因学作用。
SEN virus ( SENV) has been tentatively linked to transfusion- associated non - A - E hepatitis. We investigated SENV's role in unexplained hepatitis in other settings. Polymerase chain reaction amplification was used to detect 2 SENV variants ( SENV- D and SENV- H) in 1706 patients and control subjects. SENV was detected in 54 ( 22%) of 248 patients with acute or chronic non - A - E hepatitis, 9 ( 35%) of 26 patients with hepatitis-associated aplastic anemia, and 0 of 17 patients with cryptogenic acute liver failure, compared with 150 ( 24%) of 621 control subjects with liver disease and 76 ( 10%) of 794 healthy control subjects. When controlling for geographic region, the prevalence of SENV among case and control subjects was not significantly different. The severity of acute or chronic hepatitis A, B, or C was not influenced by coexisting SENV infection. No etiological role for SENV in the cause of cryptogenic hepatitis could be demonstrated.