Access to Chiral α-Substituted-β-Hydroxy Arylphosphonates Enabled by Biocatalytic Dynamic Reductive Kinetic Resolution
Access to Chiral α-Substituted-β-Hydroxy Arylphosphonates Enabled by Biocatalytic Dynamic Reductive Kinetic Resolution
复制标题
通过生物催化动态还原动力学分辨率获得手性α-取代-β-羟基芳基膦酸盐
DOI：
10.1039/d0ob00379d
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发表时间：
2020
影响因子：
3.2
通讯作者：
Fener Chen
中科院分区：
文献类型：
--
作者：
Zexu Wang;Yiping Zeng;Xiaofan Wu;Zihan Li;Yuan Tao;Xiaomin Yu;Zedu Huang;Fener Chen
采用酮还原酶（KRED）催化的动态还原动力学拆分法（DYRKR）合成了α-取代-β-酮基芳基膦酸酯，具有较高的分离收率（96%）、良好的非对映选择性（>99：<1 dr）和良好的对映选择性（>99% ee）。
Ketoreductase (KRED)-catalyzed dynamic reductive kinetic resolution (DYRKR) of α-substituted-β-keto arylphosphonates was developed as a generic and stereoselective approach to synthesize chiral α-substituted-β-hydroxy arylphosphonates, with moderate-to-excellent isolated yield (up to 96%), good-to-excellent diastereoselectivity (up to >99 : <1 dr), and excellent enantioselectivity (up to >99% ee) being achieved.