Surface-Enhanced Raman Spectroscopy
Surface-Enhanced Raman Spectroscopy
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DOI：
10.1146/annurev.anchem.1.031207.112814
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发表时间：
2008-01-01
影响因子：
8
通讯作者：
Van Duyne, Richard R.
中科院分区：
文献类型：
--
作者：
Stiles, Paul. L.;Dieringer, Jon A.;Van Duyne, Richard R.
控制表面大小、形状和材料的能力使表面增强拉曼光谱学（Sers）领域重新焕发了活力。由于纳米结构表面或纳米颗粒的局部表面等离子体共振的激发是Sers的核心，因此可靠控制表面特性的能力已经使Sers从一种有趣的表面现象发展成为一种快速发展的分析工具。这篇文章首先解释了Sers的许多基本特征，然后描述了使用纳米球光刻法制造高度可重复性和鲁棒性的Sers基底。特别是，我们回顾了纳米球表面上的金属膜作为几个实验的优秀候选者，这些实验曾经不可能使用更原始的Sers基底（例如，金属岛电影）。本文还介绍了应用SLAX 'S检测化学战剂和几种生物分子的进展。
The ability to control the size, shape, and material of a surface has reinvigorated the field of surface-enhanced Raman spectroscopy (SERS). Because excitation of the localized surface plasmon resonance of a nanostructured surface or nanoparticle lies at the heart of SERS, the ability to reliably control the surface characteristics has taken SERS from an interesting surface phenomenon to a rapidly developing analytical tool. This article first explains many fundamental features of SERS and then describes the use of nanosphere lithography for the fabrication of highly reproducible and robust SERS substrates. In particular, we review metal film over nanosphere surfaces as excellent candidates for several experiments that were once impossible with more primitive SERS substrates (e.g., metal island films). The article also describes progress in applying S LAX'S to the detection of chemical warfare agents and several biological molecules.