Development of a novel bioactive titanium membrane with alkali treatment for bone regeneration.
Development of a novel bioactive titanium membrane with alkali treatment for bone regeneration.
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DOI：
10.4012/dmj.2019-222
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发表时间：
2020-05
影响因子：
2.5
通讯作者：
Hanako Umehara;K. Doi;Yoshifumi Oki;R. Kobatake;Yusuke Makihara;T. Kubo;K. Tsuga
中科院分区：
文献类型：
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作者：
Hanako Umehara;K. Doi;Yoshifumi Oki;R. Kobatake;Yusuke Makihara;T. Kubo;K. Tsuga
本研究评估了一种生物活性钛膜与碱处理刺激磷灰石形成和促进骨再生。钛薄膜用NaOH处理（碱处理组）或未处理（对照组）。将每个样品在模拟体液中孵育。随后，评价表面钙沉积物的组成、其重量增加率和吸光度。然后在大鼠颅骨上钻取骨缺损，分别用各样品膜覆盖或不覆盖，测量骨组织面积比（BTA）和骨膜接触比（BMC）。两组均形成球形结晶沉淀。在碱组中，21天后，沉淀物成熟，形成磷灰石样沉淀物。碱处理组的钙、磷含量和增重率均高于对照组。碱处理组的中心区BMC高于对照组。因此，这种新型膜具有高的磷灰石形成和骨再生能力。
This study evaluates a bioactive titanium membrane with alkali treatment for stimulating apatite formation and promoting bone regeneration. The titanium thin membranes were either treated with NaOH (alkali-group) or untreated (control). Each sample were incubated in simulated body fluid. Subsequently, the composition of the surface calcium deposition, its weight increase ratio, and optical absorbance were evaluated. Then, the bone defect was trephined on the rats calvaria and covered with each sample membrane or no membrane, and the bone tissue area ratio (BTA) and bone membrane contact ratio (BMC) were evaluated. The spherical crystalline precipitates formed in both groups. In the alkali-group after 21 days, the precipitates matured, forming apatite-like precipitates. The alkali-group showed higher Ca and P contents and weight increase ratios than the control. The alkali-group exhibited a higher BMC than the control in the central area. Thus, this novel membrane has high apatite-forming and bone regeneration abilities.