Antibodies to inner ear antigens in Meniere's disease
Antibodies to inner ear antigens in Meniere's disease
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DOI：
10.1111/j.1365-2249.2004.02317.x
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发表时间：
2004-01-01
影响因子：
4.6
通讯作者：
Fattori, B
中科院分区：
文献类型：
--
作者：
Riente, L;Bongiorni, F;Fattori, B
梅尼埃病(MD)是一种以波动性听力损失、阵发性眩晕和耳鸣为特征的特发性内耳疾病。它的病因尚不清楚，尽管越来越多的证据表明自身免疫可能参与了它的发展。我们用免疫印迹法检测了一系列MD患者的血清对牛内耳抗原的反应性，这些患者此前曾被广泛研究是否存在抗胶原和膜蛋白的抗体。分别有11/25(44%)和10/25(40%)的患者与分子质量为44和53kD的内耳抗原发生反应，而健康献血员的血清中这两种抗原均为阴性。目前尚不清楚44和53kD蛋白的抗体是否在MD的发病机制中发挥作用，或者它们是否代表炎症和组织破坏的结果。即使后者是真的，它们也可能导致疾病的永久存在，或者与其他机制一起发挥辅助因素的作用。
Meniere's disease (MD) is an idiopathic inner ear disorder characterized by fluctuating hearing loss, episodic vertigo and tinnitus. Its aetiology is unknown, although there is growing evidence that autoimmunity may be involved in its development. Using the Western blot immunoassay, we examined the reactivity to bovine inner ear antigens of sera from a series of MD patients who had previously been extensively studied for the presence of antibodies to collagens and membrane proteins. Reactivity to inner ear antigens of molecular weight 44 and 53 kD was found in 11/25 (44%) and 10/25 (40%) of the patients, respectively; both antigens were absent in the sera of healthy donors. It is still unclear whether the antibodies to 44 and 53 kD proteins play a role in the pathogenesis of MD or if they instead represent the result of inflammation and tissue destruction. Even if the latter is true, they may contribute to the perpetuation of the disease or play a role as a cofactor in association with other mechanisms.