CONTRACTION-INDUCED INJURY - RECOVERY OF SKELETAL-MUSCLES IN YOUNG AND OLD MICE
CONTRACTION-INDUCED INJURY - RECOVERY OF SKELETAL-MUSCLES IN YOUNG AND OLD MICE
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DOI：
10.1152/ajpcell.1990.258.3.c436
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发表时间：
1990-03-01
影响因子：
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通讯作者：
FAULKNER, JA
中科院分区：
文献类型：
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作者：
BROOKS, SV;FAULKNER, JA
我们测试了这样一个假设，即在相同数量的收缩诱导损伤后，老年小鼠的骨骼肌再生不如年轻小鼠的肌肉。将青年和老年小鼠的趾长伸肌（EDL）暴露于15分钟的延长收缩。在第3、7、14、28和60天通过测量最大等长强直力（Po）和每个横截面的纤维数量来评估损伤量。当将延长收缩后3天的值表示为对照值的百分比时，老年小鼠肌肉的Po（约34%）和纤维数（约80%）与年轻小鼠没有差异，表明老年小鼠和年轻小鼠的肌肉损伤程度相同。到28天，幼年小鼠受伤的肌肉恢复了Po和纤维数量的对照值。相反，在28天时，老年小鼠的损伤肌肉分别恢复了Po和纤维数对照值的约84%和约87%，并且Po的不足持续到60天时。我们的结论是，受伤的肌肉再生在老年小鼠不如年轻小鼠。
We tested the hypothesis that after the same amount of contraction-induced injury, skeletal muscles in old mice regenerate less well than muscles in young mice. Extensor digitorum longus (EDL) muscles in young and old mice were exposed to 15 min of lengthening contractions. The amount of injury was evaluated at 3, 7, 14, 28, and 60 days by measurements of maximum isometric tetanic force (Po) and number of fibers per cross section. When values 3 days after lengthening contractions were expressed as a percentage of control values, the Po (.apprx.34%) and fiber number (.apprx.80%) for muscles in old mice were not different from those in young mice, suggesting that muscles in old and young mice were injured to the same degree. By 28 days, injured muscles in young mice regained control values for Po and fiber number. In contrast, at 28 days, injured muscles in old mice recovered .apprx.84 and .apprx.87% of control values for Po and fiber number, respectively, and deficits in Po persisted at 60 days. We conclude that injured muscles regenerate less well in old mice than in young mice.