Maternal serum interleukin-6 and its association with clinicopathological infectious morbidity in preterm premature rupture of membranes: a prospective cohort study
Maternal serum interleukin-6 and its association with clinicopathological infectious morbidity in preterm premature rupture of membranes: a prospective cohort study
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DOI：
10.3109/14767058.2011.638952
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发表时间：
2012-08-01
影响因子：
1.8
通讯作者：
Sharma, Deepika
中科院分区：
文献类型：
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作者：
Gulati, Shilpa;Agrawal, Swati;Sharma, Deepika
目的：分析早产胎膜早破(PPROM)孕妇血清白介素6(IL-6)水平与母胎结局的关系。方法：检测45例妊娠24~34周胎膜早破孕妇血清IL-6水平。对这些妇女进行跟踪，直到产后和胎母结局，以及胎盘和脐带的组织病理学研究。数据分析采用t检验和x(2)检验。结果：IL-6水平<8pg/ml与产后败血症和新生儿败血症显著相关。胎盘型绒毛膜羊膜炎和胃底炎的发生率分别为48.8%和13.3%，与血清IL-6水平升高和母胎感染显著相关。以IL-6浓度8pg/ml作为诊断PPROM感染的临界值，诊断PPROM感染的敏感性(82.6%)和特异性(86.3%)均优于白细胞总数(TLC)和C-反应蛋白(CRP)。结论：孕妇血清IL-6可作为预测胎膜早破临床前无症状感染的生物标志物，具有良好的敏感性和特异性。
Objective: To analyze the association of maternal serum interleukin- 6 (IL-6) with fetomaternal outcome in preterm premature rupture of membranes (PPROM). Methods: Serial serum IL-6 levels were measured in 45 women with PPROM at gestation 24-34 weeks. The women were followed till pueperium and fetomaternal outcome as well as the histopathology of the placenta and the umblical cord was studied. The data were analyzed using t test and chi(2) test. Results: IL-6 levels >= 8 pg/ml were significantly associated with puerperal sepsis and neonatal sepsis. Histological chorioamnionitis and funisitis were demonstrated in 48.8% and 13.3% women respectively and significantly correlated with elevated serum IL-6 levels and fetomaternal infection. A cut-off value of IL-6 of 8 pg/ml was found to correctly diagnose 19 out of 23 patients with infectious morbidity and showed the best sensitivity (82.6%) and specificity (86.3%) as compared to the total leucocycte count (TLC) and C-reactive protein (CRP) in diagnosing infection in PPROM. Conclusion: Maternal serum IL-6 can be used as a biomarker to predict preclinical asymptomatic infection in PPROM with good sensitivity and specificity.