Building the world's best hearing aid; regulation of cell fate in the cochlea.
Building the world's best hearing aid; regulation of cell fate in the cochlea.
复制标题
打造世界上最好的助听器；
DOI：
10.1016/j.gde.2009.06.004
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发表时间：
2009
影响因子：
4
通讯作者：
Kelley,MatthewW
中科院分区：
文献类型：
--
作者：
Puligilla,Chandrakala;Kelley,MatthewW
在哺乳动物中，听觉感知最初是通过位于卷曲耳蜗内的独特细胞类型的严格图案镶嵌中的感觉细胞介导的。鉴定指导多能祖细胞发育为每种特殊细胞类型的因素有可能增强我们对听觉系统发育的理解并确定再生治疗的潜在靶点。最近的结果已经确定了特定的信号分子和途径，包括Notch、Hedgehog、Sox2和Fgfs，它们引导祖细胞首先发育为感觉前体，称为前感觉细胞，随后发展为感觉镶嵌中的特殊细胞类型之一。
In mammals, auditory perception is initially mediated through sensory cells located in a rigorously patterned mosaic of unique cell types located within the coiled cochlea. Identification of the factors that direct multipotent progenitor cells to develop as each of these specialized cell types has the potential to enhance our understanding of the development of the auditory system and to identify potential targets for regenerative therapies. Recent results have identified specific signaling molecules and pathways, including Notch, Hedgehog, Sox2 and Fgfs, that guide progenitor cells to develop first as a sensory precursor, referred to as a prosensory cell, and subsequently as one of the specialized cell types within the sensory mosaic.