Trypanosomosis of livestock in India: A review of two decades
Trypanosomosis of livestock in India: A review of two decades
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印度牲畜锥虫病：二十年回顾
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
M. B. Chhabra
中科院分区：
文献类型：
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作者：
K. Pathak;M. B. Chhabra
锥虫病通过广泛的发病率和死亡率被列为影响印度畜牧业经济的最重要的血液原生动物疾病。虽然在全国几乎所有地区都很流行，但各州的数据显示，受各种流行病因素的影响，情况差别很大。在过去二十年中，报告了涉及牛、马、骆驼、狗和一些野生动物的暴发和个别病例。流行似乎已扩展到新的地区。报告的临床血液学变化范围很广，在宿主物种之间也各不相同，甚至进行性消瘦、贫血和间歇性发热似乎更常见。由于纯化抗原的可用性和分子生物学在寄生虫感染中的应用的发展，诊断技术已经经历了重大的改进。一些测试标准化和分析方法的出现，导致产生了更可靠的流行病学数据。基于DNA的技术使得能够表征锥虫的抗原组分。化疗和药物供应方面的进展有限。控制策略似乎没有考虑到病媒成分。实验室工作人员和实地人员之间需要加强协调，以评估目前的状况，并确定优先研究领域，以尽量减少目前的损失。
Trypanosomosis ranks as the most important haemoprotozoan disease impacting the livestock economy in India through widespread morbidity and mortality. Although prevalent in almost all parts of the country, data from different states showed wide variations being influenced by various epidemiological factors. During the last two decades, outbreaks as well as individual cases involving bovines, equids, camels, dogs and some wild animals have been reported. Endemicity appears to have extended to new areas. Reported clinico-haematological changes cover a vast range and vary between the host species, even as progressive emaciation, anaemia and intermittent fever appear to be more common. Diagnostic techniques have undergone major improvements due to availability of purified antigens and the developments in molecular biology with application in parasitic infections. Standardization of some tests and emergence of assays has led to more reliable epidemiological data being generated. DNA-based technologies have enabled the characterization of antigenic components of trypanosomes. Chemotherapy and availability of drugs have witnessed only limited progress. Control strategies do not seem to take into account the vector component. There is need for greater coordination among laboratory workers and field personnel to take stock of the present status and also to define the priority areas for research with the objective of minimizing the ongoing losses.