Human Papillomavirus Infection and Bladder Cancer Risk: A Meta-analysis
Human Papillomavirus Infection and Bladder Cancer Risk: A Meta-analysis
复制标题
人乳头瘤病毒感染与膀胱癌风险：荟萃分析
DOI：
10.1093/infdis/jir248
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发表时间：
2011-07-15
影响因子：
6.4
通讯作者：
Dai, Min
中科院分区：
文献类型：
--
作者：
Li, Ni;Yang, Lin;Dai, Min
背景尽管近年来进行的分子流行病学研究的数量增加，以评估人乳头瘤病毒（HPV）感染和膀胱癌风险之间的关联，这些研究仍然没有结论。通过汇总52项研究的数据估计膀胱癌中HPV的患病率，考虑到主要相关参数的异质性，包括研究区域，组织学类型，HPV DNA标本，出版日历期和检测方法。此外，通过对19项病例对照研究的荟萃分析，对HPV感染与膀胱癌的关系进行了检验。膀胱癌中HPV感染率为16.88%（95%可信区间[CI]，15.53%~ 18.31%），以高危型HPV感染为主（15.82% [95%CI，14.37%~ 17.36%]）。流行率因地区、HPV DNA标本类型和所用聚合酶链反应引物而异。膀胱癌的危险性显著增加（比值比2.84 [95%CI 1.39-5.80]），这也受到HPV类型、研究地区、HPV DNA标本和检测方法的影响。高危型HPV感染，特别是HPV 16，可能在膀胱癌发生中起作用。
Background. Despite an increase in the number of molecular epidemiological studies conducted in recent years to evaluate the association between human papillomavirus (HPV) infection and risk of bladder cancer, the studies remain inconclusive.Methods. The prevalence of HPV in bladder cancer was estimated by pooling data from 52 studies, taking into consideration the heterogeneity from major related parameters including study region, histological type, HPV DNA specimen, publication calendar period, and detection method. Moreover, the association of HPV infection with bladder cancer was tested by a meta-analysis with 19 case-control studies.Results. An HPV prevalence of 16.88% (95% confidence interval [CI], 15.53%-18.31%) among the bladder cancer cases was revealed, most of whom were high-risk HPV types (15.82% [95% CI, 14.37%-17.36%]). The prevalence varied by region, types of HPV DNA specimen, and polymerase chain reaction primers used. A significantly increased risk of bladder cancer was shown for the positivity of overall HPV (odds ratio, 2.84 [95% CI, 1.39-5.80]), which was also infuenced by HPV type, study region, HPV DNA specimen, and detection method.Conclusions. Infection of high-risk HPV types, especially HPV16, may play a role in bladder carcinogenesis.