Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells
Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells
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DOI：
10.1038/11375
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发表时间：
1999-08-01
期刊：
影响因子：
82.9
通讯作者：
Takashima, A
中科院分区：
文献类型：
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作者：
Matsue, H;Matsue, K;Takashima, A
树突状细胞（Dendritic cells，DC）是一类特殊的抗原提呈细胞，具有激活免疫幼稚T细胞的能力。在这里，我们报告说，与CD95配体（CD95L）cDNA转染的DC，称为“杀手”DC，提供死亡信号，而不是激活信号，T细胞抗原特异性相互作用后。致敏前将抗原致敏的杀伤DC注射入小鼠体内可诱导抗原特异性免疫抑制。致敏后给药时，杀伤DC在随后的攻击后几乎完全抑制免疫应答。因此，杀伤DC代表了一种全新的免疫调节方案，它可能直接适用于预防甚至治疗T细胞介导的炎症性疾病。
Dendritic cells (DCs) are special subsets of antigen-presenting cells characterized by their highly potent capacity to activate immunologically naive T cells. Here we report that DCs that are transfected with CD95 ligand (CD95L) cDNA, called 'killer' DCs, deliver death signals, instead of activation signals, to T cells after antigen-specific interaction. Injection of antigen-pulsed killer DCs into mice before sensitization induced antigen-specific immunosuppression. When administered after sensitization, killer DCs suppressed immune responses almost completely after subsequent challenge. Thus, killer DCs represent an entirely new immunomodulatory protocol, which may become directly applicable in preventing and even treating T cell-mediated inflammatory diseases.