Regulatory gene expressions in the ascidian ventral sensory vesicle: evolutionary relationships with the vertebrate hypothalamus
Regulatory gene expressions in the ascidian ventral sensory vesicle: evolutionary relationships with the vertebrate hypothalamus
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DOI：
10.1016/j.ydbio.2004.11.004
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发表时间：
2005-01-15
影响因子：
2.7
通讯作者：
Joly, JS
中科院分区：
文献类型：
--
作者：
Moret, F;Christiaen, L;Joly, JS
在现存的脊索动物中，神经管沿前后轴和背腹轴的整体模式是非常保守的。因此有人提出，与脊椎动物的预定前脑、中脑 - 后脑过渡区、后脑和脊髓相对应的四个区域在共同的脊索动物祖先中就已经存在。为了深入了解前神经管模式的演化，我们进行了一项研究，旨在描述玻璃海鞘（Ciona intestinalis）感觉囊泡中调控基因的表达情况，感觉囊泡是与脊椎动物前脑相关的中枢神经系统（CNS）最前端部分，处于尾芽期。所选基因主要编码参与脊椎动物前脑模式形成的转录因子的同源物。其中七个基因在腹侧感觉囊泡中表达。这些海鞘基因的一个显著特征是它们在尾芽期的表达区域受限且互补。因此，这些模式标记完善了发育中的感觉囊泡图谱。此外，它们使我们能够提出，腹侧和侧部感觉囊泡的大部分构成了一个与脊椎动物预定下丘脑相对应的模式区域。（C）2004爱思唯尔公司。保留所有权利。
In extant chordates, the overall patterning along the anteroposterior and dorsoventral axes of the neural tube is remarkably conserved. It has thus been proposed that four domains corresponding to the vertebrate presumptive forebrain, midbrain-hindbrain transition, hindbrain, and spinal cord were already present in the common chordate ancestor. To obtain insights on the evolution of the patterning of the anterior neural tube, we performed a study aimed at characterizing the expression of regulatory genes in the sensory vesicle of Ciona intestinalis, the anteriormost part of the central nervous system (CNS) related to the vertebrate forebrain. at tailbud stages. Selected genes encoded primarily for homologues of transcription factors involved in vertebrate forebrain patterning. Seven of these genes were expressed in the ventral sensory vesicle. A prominent feature of these ascidian genes is their restricted and complementary domains of expression at tailbud stages. These patterning markers thus refine the map of the developing sensory vesicle. Furthermore, they allow us to propose that a large part of the ventral and lateral sensory vesicle consists in a patterning domain corresponding to the vertebrate presumptive hypothalamus. (C) 2004 Elsevier Inc. All rights reserved.