Biochemistry examinations and health disorder evaluation of Taiwanese living near incinerators and with low serum PCDD/Fs levels
Biochemistry examinations and health disorder evaluation of Taiwanese living near incinerators and with low serum PCDD/Fs levels
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DOI：
10.1016/j.scitotenv.2005.11.004
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发表时间：
2006-08-01
影响因子：
9.8
通讯作者：
Lee, Ching-Chang
中科院分区：
文献类型：
--
作者：
Chen, Hsiu-Ling;Su, Huey-Jen;Lee, Ching-Chang
本研究的主要目的是建立背景水平的血清二恶英/Fs和生物化学的城市垃圾焚烧厂（MWI），已运行1至8年附近的居民生活，并检查血清二恶英/Fs水平和健康结果的利益之间的关联。通过问卷采访获得病史、生活方式和饮食习惯等信息。在血清PCDD/Fs水平从低到高的人群中，发现葡萄糖和血尿素氮（BUN）水平显著升高（p < 0.05），PCDD/Fs水平与葡萄糖水平呈正相关，即使在调整了年龄、性别、BMI和吸烟状况后，也与GGT水平略有相关。虽然没有结论性的结果与我们的研究参与者的血清二恶英/Fs的积累，我们认为，目前的生化检查只反映了部分的生理变化，葡萄糖调节和肝功能。然而，低血清PCDD/Fs水平似乎不足以引发糖尿病或肝脏相关疾病的病理过程。研究结果表明，人体的生物化学功能，如肝脏和葡萄糖调节受到影响的多氯二苯并对二恶英/Fs的接触，即使在这些低血清中发现的多氯二苯并对二恶英/Fs的水平在一般人群。因此，应进一步分析其他生化功能，特别是与免疫功能相关的功能。(c)2005 Elsevier B.V保留所有权利。
The main objective of this study was to establish background levels of serum PCDD/Fs and biochemistry of residents living near municipal waste incinerators (MWIs) which had been operating between I and 8 years, and also to examine the association between the serum PCDD/Fs levels and health outcomes of interest. Information on medical history, life-style, and dietary habits was obtained by questionnaire interview. Significantly elevated levels of glucose and blood urea nitrogen (BUN) were found in those with low to high serum PCDD/Fs levels (p < 0.05), and PCDD/Fs levels were found to be positively associated with glucose levels, and marginally with GGT levels even after adjusting for age, sex, BMI and smoking status. Although no conclusive findings on health disorder were associated with the accumulation of serum PCDD/Fs in our study participants, we suggest that the current biochemistry examinations only reflect partially the physiological change in glucose modulation and liver function. However, the low serum PCDD/Fs level does not seem to be sufficient in eliciting pathological process for diabetes or liver-related diseases. The findings suggest that the human body's biochemistry functions such as liver and glucose modulation were affected by PCDD/Fs exposure at even these low serum PCDD/Fs levels found in the general population. Other biochemical functions therefore should be further analyzed, especially for hormone-related and immune functions. (c) 2005 Elsevier B.V All rights reserved.