Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age
复制标题
DOI：
10.1038/s41467-019-14161-7
复制
发表时间：
2020-02-10
影响因子：
16.6
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Harris, Sarah E.;Cox, Simon R.;Deary, Ian J.
如果我们要确定与老年认知功能相关的生物标志物，并开发有助于减少与年龄相关的认知衰退的治疗方法，那么确定老年认知功能的生物学相关性是很重要的。在这里，我们研究了洛锡安出生队列1936 （LBC1936， N=798）、洛锡安出生队列1921 （LBC1921， N=165）和INTERVAL BioResource （N=4451）中90种神经学相关蛋白（Olink (R)蛋白质组学）的血浆水平与一般流体认知能力之间的关系。在LBC1936中，22种蛋白质与一般流体认知能力显著相关（β值在-0.11至-0.17之间）。mri评估了总脑容量部分介导了其中10种蛋白质与一般流体认知能力之间的关联。在INTERVAL的年龄匹配子样本中，22种蛋白质的效应大小虽然较小，但都与LBC1936的方向相同。一些神经学相关蛋白的血浆水平与晚年的一般流体认知能力有关，在某些情况下由脑容量介导。
Identifying biological correlates of late life cognitive function is important if we are to ascertain biomarkers for, and develop treatments to help reduce, age-related cognitive decline. Here, we investigated the associations between plasma levels of 90 neurology-related proteins (Olink (R) Proteomics) and general fluid cognitive ability in the Lothian Birth Cohort 1936 (LBC1936, N=798), Lothian Birth Cohort 1921 (LBC1921, N=165), and the INTERVAL BioResource (N=4451). In the LBC1936, 22 of the proteins were significantly associated with general fluid cognitive ability (beta between -0.11 and -0.17). MRI-assessed total brain volume partially mediated the association between 10 of these proteins and general fluid cognitive ability. In an age-matched subsample of INTERVAL, effect sizes for the 22 proteins, although smaller, were all in the same direction as in LBC1936. Plasma levels of a number of neurology-related proteins are associated with general fluid cognitive ability in later life, mediated by brain volume in some cases.