Effect of Eu doping concentration on fluorescence and magnetic resonance imaging properties of Gd2O3:Eu3+ nanoparticles used as dual-modal contrast agent
Effect of Eu doping concentration on fluorescence and magnetic resonance imaging properties of Gd2O3:Eu3+ nanoparticles used as dual-modal contrast agent
复制标题
Eu掺杂浓度对双模态造影剂Gd2O3:Eu3纳米粒子荧光和磁共振成像性能的影响
DOI：
10.1088/1361-6528/aad347
复制
发表时间：
2018-10-12
期刊：
影响因子：
3.5
通讯作者：
Chen, Dihu
中科院分区：
文献类型：
--
作者：
Deng, Huawei;Chen, Fei;Chen, Dihu
铕掺杂氧化钆（Gd2O3:Eu3+）纳米粒子（NPs）具有良好的性能，可用于荧光成像（FI）和磁共振成像（MRI）双模态造影剂，在生物医学应用中引起了强烈关注。然而，通过调整掺杂浓度来平衡 FI 和 MRI 的信息有限。在这项研究中，通过简单且通用的液体激光烧蚀（LAL）技术制备了具有不同Eu3+掺杂浓度的Gd2O3:Eu3+ NP。研究了Eu3+掺杂浓度对荧光性质和纵向弛豫率的影响。确定兼具高荧光特性和纵向弛豫率的最佳Eu3+掺杂浓度为5%。结构、形貌和组成的表征表明这些纳米颗粒具有良好的结晶度和优异的分散性。这些结果表明，LAL 制备的 Gd2O3:Eu3+ NPs 有望成为高效 FI 和 MRI 双模态造影剂。
Europium-doped gadolinium oxide (Gd2O3:Eu3+) nanoparticles (NPs) with favorable properties for use in fluorescence imaging (FI) and magnetic resonance imaging (MRI) dual-modal contrast agent has attracted intense attention in biomedical applications. However, limited information is available on balancing FI and MRI by adjusting doping concentrations. In this study, Gd2O3:Eu3+ NPs with various Eu3+ doping concentrations were prepared by the facile and general technique of laser ablation in liquid (LAL). The influence of Eu3+-doping concentration on fluorescence properties and longitudinal relaxivity were investigated. The optimum Eu3+-doping concentration with both high fluorescence properties and longitudinal relaxivity was determined to be 5%. The characterization of the structure, morphology, and composition shows that these NPs possess good crystallinity and excellent dispersibility. These results show that Gd2O3:Eu3+ NPs prepared by LAL are promising candidates for highly efficient FI and MRI dual-modal contrast agents.