[Cytogenetic studies of spontaneous abortions in humans].
[Cytogenetic studies of spontaneous abortions in humans].
复制标题
[人类自然流产的细胞遗传学研究]。
DOI：
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发表时间：
1990
期刊：
影响因子：
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通讯作者：
C. R. Zhou
中科院分区：
文献类型：
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作者：
C. R. Zhou
采用定向法对52例自然流产标本的绒毛膜绒毛染色体制备进行核型分析。对 51 份人工流产标本进行了平行细胞遗传学研究。在 52 例自然流产标本中，11 例（21%）染色体异常，其中 82% 被发现具有常染色体三体性（3、14、16、19、20 和 21）。 16 三体是最常见的异常，占三体流产的 44%。检测到双三体流产，核型为 48、XX、+16、+20。这些结果表明，染色体异常是自然流产的重要原因。讨论自然流产染色体异常及其相关因素之间的关系。
Karyotypes were analyzed using directing method for chorionic villi chromosome preparation in 52 specimens from spontaneous abortions. A paralleled cytogenetic study of 51 specimens from induced abortions was carried out. Among 52 specimens from spontaneous abortions, 11 (21%) were chromosomally abnormal and 82% of these were found to have autosomal trisomies (3,14,16,19,20 and 21). Trisomy 16 was the most common abnormality accounting for 44% of trisomic abortuses. A double trisomic abortus with a 48, XX, +16, +20 karyotype was detected. These results showed that chromosome abnormality is an important cause of spontaneous abortion. The relationship between chromosomal abnormalities of spontaneous abortuses and the factors relevant to the abnormalities are discussed.